Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Center for Drug Delivery Research, Tokyo University of Science, Chiba, Japan.
Anticancer Res. 2020 May;40(5):2701-2706. doi: 10.21873/anticanres.14241.
BACKGROUND/AIM: Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement.
A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. The doses of 5-FU and acetic acid were examined, and a treatment experiment using Kenalog® was performed.
The optimal dose of the 5-FU solution and the optimal concentration of the acetic acid aqueous solution were 40 mg/kg and 25%, respectively. Treatment with Kenalog® confirmed that this model mimics immunocompromised oral mucositis.
Compared with a mouse model, oral mucositis can be easily observed in this model and provides a large amount of oral mucosal tissue.
背景/目的：癌症治疗中常发生口腔黏膜炎，这是一个主要问题。本研究旨在建立一种用于定量测量的癌症化疗诱导口腔黏膜炎的大鼠模型。
通过向先前给予 5-FU 溶液的大鼠颊黏膜内注射醋酸水溶液制备口腔黏膜炎模型动物。检查了 5-FU 和醋酸的剂量，并进行了使用 Kenalog®的治疗实验。
5-FU 溶液的最佳剂量和醋酸水溶液的最佳浓度分别为 40mg/kg 和 25%。用 Kenalog®进行治疗证实，该模型模拟了免疫功能低下的口腔黏膜炎。
与小鼠模型相比，该模型中口腔黏膜炎更容易观察，并提供了大量的口腔黏膜组织。
