使用 5-氟尿嘧啶诱导的口腔黏膜炎大鼠模型研究 GGsTop 对口腔黏膜胶原和谷胱甘肽的影响。
Effects of GGsTop on Collagen and Glutathione in the Oral Mucosa Using a Rat Model of 5-Fluorouracil-Induced Oral Mucositis.
机构信息
Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Center for Drug Delivery Research, Tokyo University of Science, Chiba, Japan.
出版信息
In Vivo. 2021 Jan-Feb;35(1):175-180. doi: 10.21873/invivo.12246.
BACKGROUND/AIM: To evaluate the usefulness of GGsTop for oral mucositis, a quantitative study focusing on oral mucosal tissues is necessary. In this study, we aimed to quantify collagen and glutathione using a rat model of 5-fluorouracil-induced oral mucositis.
MATERIALS AND METHODS
Changes in ulcer area and erythrocyte count were measured to confirm the usefulness of GGsTop for oral mucositis. The effect of GGsTop on collagen was evaluated by observing oral mucosal tissue sections and measuring the collagen concentration in the tissues. The total glutathione concentration and the oxidized glutathione concentration were measured, and the concentration of the reduced form was calculated.
RESULTS
GGsTop shortened the treatment period for oral mucositis without affecting the white blood cell count. In addition, GGsTop promoted collagen production and alleviated oxidative stress conditions.
CONCLUSION
GGsTop affects collagen and glutathione in the treatment of oral mucositis.
背景/目的：为了评估 GGsTop 对口腔黏膜炎的有效性，有必要进行一项专注于口腔黏膜组织的定量研究。在这项研究中，我们旨在使用 5-氟尿嘧啶诱导的口腔黏膜炎大鼠模型来定量检测胶原蛋白和谷胱甘肽。
材料和方法
通过测量溃疡面积和红细胞计数来确认 GGsTop 对口腔黏膜炎的有效性。通过观察口腔黏膜组织切片并测量组织中的胶原蛋白浓度来评估 GGsTop 对胶原蛋白的影响。测量总谷胱甘肽浓度和氧化型谷胱甘肽浓度，并计算还原型浓度。
结果
GGsTop 缩短了口腔黏膜炎的治疗时间，而不影响白细胞计数。此外，GGsTop 促进了胶原蛋白的产生，并缓解了氧化应激状态。
结论
GGsTop 影响口腔黏膜炎治疗中的胶原蛋白和谷胱甘肽。
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