Department of Otorhinolaryngology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Via Salvator Allende 43, Salerno, Italy.
Eur Arch Otorhinolaryngol. 2020 Oct;277(10):2673-2679. doi: 10.1007/s00405-020-05998-6. Epub 2020 May 4.
Acinic cell carcinoma (ACCs) is uncommon malignant epithelial neoplasm of the salivary glands; the most common presentation is a well-defined painless solid mass. Diagnosis of ACCs is frequently complicated, due to its similarity with benign tumors.
A review of the literature available on ACCs was carried out. Studies were sourced from PubMed with searching of relevant headings and sub-headings and cross-referencing.
There are no clear characteristics of ACCs found on CT, MRI and ultrasound imaging. The management of the ACC, a rare malignancy of the parotid gland, is often difficult and controversial. Radical surgery is the best treatment option. The role of radiotherapy remains controversial: the precise indications and oncologic effects of adjuvant radiotherapy in ACC of the parotid gland are not well known. There is insufficient literature regarding the chemotherapy for metastatic ACC.
Knowledge about ACC, a rare malignancy of parotid gland, has changed over the past few decades. More clinical randomized works would be needed, both to assess the real effectiveness of radio and chemotherapy and to have an unanimous consensus about their indications.
涎腺的闰管细胞癌（ACC）是一种罕见的恶性上皮性肿瘤，最常见的表现为界限清楚的无痛性实性肿块。由于其与良性肿瘤相似，ACC 的诊断常常很复杂。
对 ACC 的相关文献进行了回顾。研究资料来源于 PubMed，检索了相关的标题和副标题，并进行了交叉参考。
在 CT、MRI 和超声成像上，ACC 没有明显的特征。由于腮腺的 ACC 是一种罕见的恶性肿瘤，其治疗往往具有挑战性且存在争议。根治性手术是最佳治疗选择。放射治疗的作用仍存在争议：腮腺 ACC 辅助放疗的确切适应证和肿瘤学效果尚不清楚。关于转移性 ACC 的化疗，文献也不足。
过去几十年中，人们对腮腺罕见恶性肿瘤 ACC 的认识发生了变化。需要更多的临床随机研究，以评估放化疗的真正效果，并就其适应证达成一致意见。
