评估免疫功能低下小鼠中的寨卡病毒发病机制。

Evaluating Zika Virus Pathogenesis in Immunocompromised Mice.

机构信息

Zoonotic Diseases and Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

出版信息

Methods Mol Biol. 2020;2142:23-40. doi: 10.1007/978-1-0716-0581-3_3.

DOI:10.1007/978-1-0716-0581-3_3

PMID:32367356

Abstract

Mouse models of Zika virus (ZIKV) infection, which recapitulate certain aspects of ZIKV infection in humans, have demonstrated their utility for studying ZIKV pathogenesis and for the initial screening of antivirals, experimental therapeutics, and candidate vaccines for protective efficacy against ZIKV infection. In this chapter we outline the available mouse models and describe the evaluation of ZIKV pathogenesis in an immunocompromised mouse model of ZIKV infection.

摘要

寨卡病毒（ZIKV）感染的小鼠模型可以再现人类感染 ZIKV 的某些方面，这些模型已被证明可用于研究 ZIKV 的发病机制，并可初步筛选针对 ZIKV 感染的抗病毒药物、实验性治疗方法和候选疫苗的保护效力。在本章中，我们概述了现有的小鼠模型，并描述了在免疫功能低下的 ZIKV 感染小鼠模型中评估 ZIKV 发病机制的方法。