米拉贝隆治疗膀胱过度活动症：高龄患者的安全性和疗效。
Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient.
机构信息
University of Alberta, Division of Geriatric Medicine, Edmonton, Alberta, Canada.
Great Western Hospitals NHS Foundation Trust, Swindon SN3 6BB, UK.
出版信息
Clin Interv Aging. 2020 Apr 23;15:575-581. doi: 10.2147/CIA.S174402. eCollection 2020.
Abstract
Lower urinary tract symptoms, including urgency, urgency incontinence, frequency, and nocturia, are highly prevalent in older adults and are associated with significant morbidity and impairment in quality of life. When conservative measures such as bladder training fail to improve symptoms, pharmacological management is recommended by national and international guidelines. Mirabegron, an agonist of the β3 adrenergic receptor, demonstrates similar efficacy to the anticholinergic drugs without the risk of anticholinergic effects, but experience and evidence in the very elderly population are limited. This narrative review examines the current evidence base for mirabegron in very elderly adults.
摘要
下尿路症状，包括尿急、急迫性尿失禁、尿频和夜尿，在老年人中非常普遍，并与显著的发病率和生活质量受损相关。当保守措施，如膀胱训练未能改善症状时，国家和国际指南建议进行药物治疗。米拉贝隆是一种β3 肾上腺素能受体激动剂，其疗效与抗胆碱能药物相似，而没有抗胆碱能作用的风险，但在非常老年人群中的经验和证据有限。本综述探讨了米拉贝隆在非常老年人群中的现有证据基础。
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