Karthik Sheshachala, Sharma Lavanya P, Narayanaswamy Janardhanan C
OCD Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India.
Neuropsychiatr Dis Treat. 2020 Apr 17;16:1003-1013. doi: 10.2147/NDT.S211703. eCollection 2020.
Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (CNS) functions, including excitotoxicity and neuronal migration. It is implicated in the pathogenesis of various neuropsychiatric disorders including epilepsy, Parkinson's disease, Alzheimer's dementia, schizophrenia and obsessive compulsive disorder (OCD). Over the years, a growing body of evidence has helped researchers understand the mechanisms underlying glutamatergic involvement in the pathogenesis of these disorders. In this review, we attempt to elucidate the role of glutamate in OCD, which is a chronic psychiatric condition with significant morbidity. This article provides current perspectives on the role played by glutamate in the pathogenesis, clinical symptoms and treatment response in OCD, a critical analysis of existing and emerging evidence, both clinical and preclinical, followed by a summary and future directions.
谷氨酸是一种广泛存在的兴奋性神经递质，参与正常生理过程以及包括兴奋性毒性和神经元迁移在内的多种中枢神经系统（CNS）功能。它与包括癫痫、帕金森病、阿尔茨海默病性痴呆、精神分裂症和强迫症（OCD）在内的各种神经精神疾病的发病机制有关。多年来，越来越多的证据帮助研究人员了解谷氨酸能在这些疾病发病机制中的作用机制。在本综述中，我们试图阐明谷氨酸在强迫症中的作用，强迫症是一种具有显著发病率的慢性精神疾病。本文提供了关于谷氨酸在强迫症发病机制、临床症状和治疗反应中所起作用的当前观点，对现有和新出现的临床和临床前证据进行了批判性分析，随后进行了总结和展望未来方向。
