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基于倾向评分匹配的机器人腹腔镜辅助直肠癌根治术治疗局部晚期直肠癌:中国一家结直肠中心的短期疗效

Robotic- laparoscopic-assisted proctectomy for locally advanced rectal cancer based on propensity score matching: Short-term outcomes at a colorectal center in China.

作者信息

Ye Shan-Ping, Zhu Wei-Quan, Liu Dong-Ning, Lei Xiong, Jiang Qun-Guang, Hu Hui-Min, Tang Bo, He Peng-Hui, Gao Geng-Mei, Tang He-Chun, Shi Jun, Li Tai-Yuan

机构信息

Department of General Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.

Department of Graduate Student, Jiangxi Medical College of Nanchang University, Nanchang 330006, Jiangxi Province, China.

出版信息

World J Gastrointest Oncol. 2020 Apr 15;12(4):424-434. doi: 10.4251/wjgo.v12.i4.424.

Abstract

BACKGROUND

Reports in the field of robotic surgery for rectal cancer are increasing year by year. However, most of these studies enroll patients at a relatively early stage and have small sample sizes. In fact, studies only on patients with locally advanced rectal cancer (LARC) and with relatively large sample sizes are lacking.

AIM

To investigate whether the short-term outcomes differed between robotic-assisted proctectomy (RAP) and laparoscopic-assisted proctectomy (LAP) for LARC.

METHODS

The clinicopathological data of patients with LARC who underwent robotic- or laparoscopic-assisted radical surgery between January 2015 and October 2019 were collected retrospectively. To reduce patient selection bias, we used the clinical baseline characteristics of the two groups of patients as covariates for propensity-score matching (PSM) analysis. Short-term outcomes were compared between the two groups.

RESULTS

The clinical features were well matched in the PSM cohort. Compared with the LAP group, the RAP group had less intraoperative blood loss, lower volume of pelvic cavity drainage, less time to remove the pelvic drainage tube and urinary catheter, longer distal resection margin and lower rates of conversion ( < 0.05). However, the time to recover bowel function, the harvested lymph nodes, the postoperative length of hospital stay, and the rate of unplanned readmission within 30 days postoperatively showed no difference between the two groups ( 0.05). The rates of total complications and all individual complications were similar between the RAP and LAP groups ( 0.05).

CONCLUSION

This retrospective study indicated that RAP is a safe and feasible method for LARC with better short-term outcomes than LAP, but we have to admit that the clinically significant of part of indicators are relatively small in the practical situation.

摘要

背景

直肠癌机器人手术领域的报道逐年增加。然而,这些研究大多纳入相对早期的患者,且样本量较小。事实上,缺乏仅针对局部晚期直肠癌(LARC)患者且样本量相对较大的研究。

目的

探讨机器人辅助直肠切除术(RAP)与腹腔镜辅助直肠切除术(LAP)治疗LARC的短期疗效是否存在差异。

方法

回顾性收集2015年1月至2019年10月期间接受机器人或腹腔镜辅助根治性手术的LARC患者的临床病理资料。为减少患者选择偏倚,我们将两组患者的临床基线特征作为协变量进行倾向评分匹配(PSM)分析。比较两组的短期疗效。

结果

PSM队列中临床特征匹配良好。与LAP组相比,RAP组术中出血量更少、盆腔引流量更低、盆腔引流管和导尿管拔除时间更短、远端切缘更长且中转率更低(<0.05)。然而,两组间肠功能恢复时间、收获的淋巴结数量、术后住院时间以及术后30天内非计划再入院率无差异(>0.05)。RAP组和LAP组的总并发症发生率和所有个体并发症发生率相似(>0.05)。

结论

这项回顾性研究表明,RAP是一种安全可行的LARC治疗方法,短期疗效优于LAP,但我们必须承认,在实际情况中部分指标的临床意义相对较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad75/7191331/81feb675ff7d/WJGO-12-424-g001.jpg

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