Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Pharmacy, Anhui Provincial Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Br J Pharmacol. 2020 Jul;177(14):3147-3161. doi: 10.1111/bph.15092. Epub 2020 Jun 5.
As of April 9, 2020, a novel coronavirus (SARS-CoV-2) had caused 89,931 deaths and 1,503,900 confirmed cases worldwide, which indicates an increasingly severe and uncontrollable situation. Initially, little was known about the virus. As research continues, we now know the genome structure, epidemiological and clinical characteristics, and pathogenic mechanisms of SARS-CoV-2. Based on this knowledge, potential targets involved in the processes of virus pathogenesis need to be identified, and the discovery or development of drugs based on these potential targets is the most pressing need. Here, we have summarized the potential therapeutic targets involved in virus pathogenesis and discuss the advances, possibilities, and significance of drugs based on these targets for treating SARS-CoV-2. This review will facilitate the identification of potential targets and provide clues for drug development that can be translated into clinical applications for combating SARS-CoV-2.
截至 2020 年 4 月 9 日，一种新型冠状病毒（SARS-CoV-2）已在全球范围内造成 89931 人死亡和 1503900 例确诊病例，这表明情况日益严重且难以控制。最初，人们对该病毒知之甚少。随着研究的不断深入，我们现在已经了解了 SARS-CoV-2 的基因组结构、流行病学和临床特征以及发病机制。在此基础上，需要确定与病毒发病过程相关的潜在靶点，并基于这些潜在靶点发现或开发药物是最紧迫的需求。在这里，我们总结了与病毒发病机制相关的潜在治疗靶点，并讨论了基于这些靶点的药物在治疗 SARS-CoV-2 方面的进展、可能性和意义。本综述将有助于确定潜在靶点，并为药物开发提供线索，这些线索可转化为抗击 SARS-CoV-2 的临床应用。
