基于PET/CT成像中颈部淋巴结代谢活性的比例评估对喉癌患者的预测价值
The Predictive Value of Proportional Evaluation Based on the Metabolic Activity of Cervical Lymph Nodes on PET/CT Imaging in Patients with Larynx Cancer.
作者信息
Sağlampınar Karyağar Sevda, Karyağar Savaş, Güven Osman, Üstün Onur, Atar Yavuz, Uyar Yavuz
机构信息
University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.
University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Otorhinolaryngology, İstanbul, Turkey.
出版信息
Mol Imaging Radionucl Ther. 2020 Apr 29;29(2):59-64. doi: 10.4274/mirt.galenos.2019.92300.
OBJECTIVES
We aimed to evaluate the proportional values of maximum standardized uptake value (SUV) for cervical lymph nodes on F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prediction of the presence of metastasis in patients with larynx squamous cell cancer (LSCC).
METHODS
This retrospective study involved 43 patients with LSCC. All patients underwent resection of the primary tumor and neck dissection within 4 weeks after undergoing F-FDG PET/CT examinations. Receiver operating characteristic (ROC) analysis was performed to evaluate the lymph node SUV/primary tumor SUV (SUVLN/SUVPT), lymph node SUV/aortic SUV (SUVLN/SUVA), and lymph node SUV/ liver SUV (SUVLN/SUVL) ratios for diagnosis of lymph node metastasis.
RESULTS
SUVLN/SUVA, SUVLN/SUVL, and SUVLN/SUVPT rates were significantly higher in metastatic lymph nodes compared to non-metastatic nodes. ROC analysis for metastasis showed that the cut-off thresholds were 3.87 for SUVLN; 1.78 for SUVLN /SUVA; 1.08 for SUVLN/SUVL; and 0.36 for SUVLN/SUVPT. The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUVLN; 79.7%, 84%, 1.78 for SUVLN/SUVA; 84.1%, 76%, 0.833 for SUVLN/SUVL; and 53.6%, 76%, 0.666 for SUVLN/SUVPT, respectively.
CONCLUSION
SUVLN/SUVA, SUVLN/SUVL, and SUVLN/SUVPT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC.
目的
我们旨在评估氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）上喉鳞状细胞癌（LSCC）患者颈部淋巴结最大标准化摄取值（SUV）的比例值，以预测转移的存在。
方法
这项回顾性研究纳入了43例LSCC患者。所有患者在接受F-FDG PET/CT检查后4周内进行了原发肿瘤切除和颈部清扫。进行受试者操作特征（ROC）分析，以评估淋巴结SUV/原发肿瘤SUV（SUVLN/SUVPT）、淋巴结SUV/主动脉SUV（SUVLN/SUVA）和淋巴结SUV/肝脏SUV（SUVLN/SUVL）比值对淋巴结转移的诊断价值。
结果
与非转移淋巴结相比，转移淋巴结中的SUVLN/SUVA、SUVLN/SUVL和SUVLN/SUVPT率显著更高。转移的ROC分析显示，SUVLN的截断阈值为3.87；SUVLN/SUVA为1.78；SUVLN/SUVL为1.08；SUVLN/SUVPT为0.36。SUVLN的诊断敏感性、特异性和AUC分别为83.7%、77%、0.856；SUVLN/SUVA为79.7%、84%、0.78；SUVLN/SUVL为84.1%、76%、0.833；SUVLN/SUVPT为53.6%、76%、0.666。
结论
SUVLN/SUVA、SUVLN/SUVL和SUVLN/SUVPT比值可安全用于LSCC患者颈部淋巴结转移的诊断。
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