Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India.
Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia, 42300, Selangor, Darul Ehsan, Malaysia.
Mini Rev Med Chem. 2020;20(13):1311-1317. doi: 10.2174/1389557520666200505124125.
Being derived from primary amine and aromatic aldehyde, Schiff base and their complexes have an imperative role in the improvement of inorganic chemistry, which are broadly studied as coordination compounds and are gradually becoming more important in biochemical and analytical applications.
They have also been used for antibacterial, antifungal, anticancer, antitubercular activities. Novel synthesised Schiff's base 2-methoxy-4-((3-methylpyridin-2-ylimino)methyl)phenol (SB) and its metal complexes (Zn[II], Cu[II], Co[II] and Ni[II]) were characterised by UV, IR and NMR spectroscopy. Formation of the Schiff base and the metal (Zn[II], Cu[II], Co[II] and Ni[II]) chelates was supported by spectral and analytical data. The ligand and metal complexes have been screened for their antibacterial activity against Staphylococcus aureus, Salmonella typhi, Escherichia coli, Klebsiella pneumoniae and antifungal activity against the fungi Candida albicans and Aspergillus niger. Further, the synthesised compounds were also screened for antiproliferative activity against the human colorectal carcinoma (HCT116) cell line using the Sulforhodamine B assay.
Metal complexes formed were found to enhance the potency of the Schiff base due to coordination with a copper complex, showing better activity than others.
Copper complex was observed to be more potent than other complexes against all the pathogenic microbes and cancer cell line (HCT116).
席夫碱及其配合物来源于伯胺和芳香醛，在无机化学的改进中具有重要作用，它们被广泛研究为配位化合物，并在生化和分析应用中逐渐变得更加重要。
它们也被用于抗菌、抗真菌、抗癌、抗结核活性。新合成的席夫碱 2-甲氧基-4-((3-甲基吡啶-2-亚基)亚甲基)苯酚（SB）及其金属配合物（Zn[II]、Cu[II]、Co[II]和 Ni[II]）通过 UV、IR 和 NMR 光谱进行了表征。席夫碱和金属（Zn[II]、Cu[II]、Co[II]和 Ni[II]）配合物的形成得到了光谱和分析数据的支持。对配体和金属配合物进行了抗菌活性（金黄色葡萄球菌、伤寒沙门氏菌、大肠杆菌、肺炎克雷伯菌）和抗真菌活性（白色念珠菌、黑曲霉）的筛选。此外，还使用磺基罗丹明 B 测定法对合成化合物的抗增殖活性（人结直肠癌细胞系 HCT116）进行了筛选。
发现金属配合物由于与铜配合物的配位作用而增强了席夫碱的活性。
与其他配合物相比，铜配合物对所有致病菌和癌细胞系（HCT116）都表现出更强的活性。
