Miyamoto Keisuke, Funahashi Yu, Yoshino Yuta, Kawabe Kentaro, Yamazaki Kiyohiro, Ozaki Yuki, Mori Yoko, Ochi Shinichiro, Iga Jun-Ichi, Ueno Shu-Ichi
Department of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
Department of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
Asian J Psychiatr. 2020 Aug;52:102112. doi: 10.1016/j.ajp.2020.102112. Epub 2020 Apr 19.
CTL-associated antigen 4 (CTLA4) and its downstream signals compose an important mechanism that suppresses immune activity. Recent studies have shown that immune abnormalities are associated with the pathogenesis of schizophrenia (SCZ), but little research has been performed on the relevance of CTLA4 and SCZ. In the present study, we investigated the relationship between CTLA4 mRNA expression and SCZ. We examined the expression of CTLA4 mRNA in blood from patients with SCZ, bipolar disorder (BD), and major depressive disorder (MDD). We compared 50 SCZ subjects, 46 BD subjects, and 63 MDD subjects with age- and sex-matched healthy controls (HCs). Quantitative real-time PCR was performed to examine CTLA4 mRNA expression in peripheral blood using TaqMan probes. Levels of CTLA4 mRNA expression were significantly lower in patients with SCZ compared with HCs (p < 0.001), whereas no differences were found between affective disorder (BD and MDD) patients and HCs. We analyzed the correlation between CTLA4 mRNA expression and clinical parameters, but no significant correlation was found. The expression of CTLA4 mRNA was lower specifically in SCZ, suggesting that abnormal CTLA4 expression may be particularly related to the pathogenesis of SCZ. CTLA4 may be a useful diagnostic marker and a potential therapeutic target of SCZ.
细胞毒性T淋巴细胞相关抗原4（CTLA4）及其下游信号构成了一种抑制免疫活性的重要机制。最近的研究表明，免疫异常与精神分裂症（SCZ）的发病机制有关，但关于CTLA4与SCZ相关性的研究较少。在本研究中，我们调查了CTLA4 mRNA表达与SCZ之间的关系。我们检测了SCZ患者、双相情感障碍（BD）患者和重度抑郁症（MDD）患者血液中CTLA4 mRNA的表达。我们将50名SCZ受试者、46名BD受试者和63名MDD受试者与年龄和性别匹配的健康对照（HCs）进行了比较。使用TaqMan探针进行定量实时PCR以检测外周血中CTLA4 mRNA的表达。与HCs相比，SCZ患者的CTLA4 mRNA表达水平显著降低（p < 0.001），而情感障碍（BD和MDD）患者与HCs之间未发现差异。我们分析了CTLA4 mRNA表达与临床参数之间的相关性，但未发现显著相关性。CTLA4 mRNA的表达在SCZ中特异性降低，表明CTLA4表达异常可能与SCZ的发病机制特别相关。CTLA4可能是SCZ的一个有用的诊断标志物和潜在的治疗靶点。
