Rheumatology Service, Hospital Universitario "Dr. José Eleuterio Gonzalez", Universidad Autónoma de Nuevo León, Av. Gonzalitos 235 Norte, Colonia Mitras Centro, C.P 64460, Monterrey, Nuevo León, Mexico.
Rheumatol Int. 2020 Sep;40(9):1433-1438. doi: 10.1007/s00296-020-04591-8. Epub 2020 May 5.
Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in women in reproductive age. We conducted an observational, single-center, cross-sectional, and descriptive study in reproductive-age, non-pregnant women without a prior psychiatric diagnosis. Differences between disease groups, subscale results, and disease activity were analyzed with the Chi square, Mann-Whitney U test, or Kruskal-Wallis test. A total of 100 women were included. Mean age was 35.3 years (SD = 10.07). The most frequent diagnosis was rheumatoid arthritis (RA) with 48, followed by systemic lupus erythematosus (SLE) with 30. A total of 66 (66%) patients had an abnormal HADS score (probable or possible cases) in either subscale. More than 50% of RA patients had an abnormal HADS score. We found an association between RA disease activity groups and total HADS score (p = 0.003). Furthermore, we found a statically significant association between RA activity groups and HADS anxiety subscales group classification (p = 0.01). No differences between disease activity groups of SLE or other diseases and HADS classification or total score was found (p = 0.277). A high frequency of probable or possible cases of depression and anxiety were recognized in reproductive-age women with RD. A high RA disease activity was associated with a high total HADS score and an increased presence of anxiety symptoms.
生育年龄的风湿性疾病（RD）女性尤其容易出现抑郁和焦虑，这会对妊娠、分娩和 RD 产生负面影响。本研究的目的是描述采用医院焦虑和抑郁量表（HADS）评估生育年龄女性焦虑和抑郁症状的频率。我们进行了一项观察性、单中心、横断面和描述性研究，纳入了无先前精神科诊断的生育年龄、未怀孕的女性。采用卡方检验、Mann-Whitney U 检验或 Kruskal-Wallis 检验分析疾病组之间、亚量表结果和疾病活动之间的差异。共纳入 100 名女性。平均年龄为 35.3 岁（标准差 = 10.07）。最常见的诊断是类风湿关节炎（RA），共 48 例，其次是系统性红斑狼疮（SLE），共 30 例。共有 66 名（66%）患者 HADS 评分异常（可能或可能病例），无论是在亚量表中。超过 50%的 RA 患者 HADS 评分异常。我们发现 RA 疾病活动组与总 HADS 评分之间存在关联（p = 0.003）。此外，我们发现 RA 活动组与 HADS 焦虑亚量表组分类之间存在统计学显著关联（p = 0.01）。未发现 SLE 或其他疾病的疾病活动组与 HADS 分类或总分之间存在差异（p = 0.277）。在生育年龄的 RD 女性中，识别出了较高频率的可能或可能病例的抑郁和焦虑。高 RA 疾病活动与高总 HADS 评分和增加的焦虑症状有关。
