Varich N L, Gubareva L V, Kaverin N V
Mol Gen Mikrobiol Virusol. 1988 Nov(11):35-40.
Interrelationships between the level of protein synthesis and the pattern of virus-specific transcription in influenza virus-infected cells have been studied with the use of a wide range of concentrations of a protein synthesis inhibitor (cycloheximide). The obtained data reveal a predominant stimulation of the transcription for some viral genes by partial suppression of protein synthesis. The data also suggest the existence of cRNA (full transcripts) synthesis regulation, in addition to the regulation of vRNA and mRNA synthesis described earlier.
利用一系列不同浓度的蛋白质合成抑制剂(环己酰亚胺),对流感病毒感染细胞中蛋白质合成水平与病毒特异性转录模式之间的相互关系进行了研究。所获得的数据表明,部分抑制蛋白质合成可对某些病毒基因的转录产生显著刺激作用。这些数据还表明,除了先前描述的对病毒RNA(vRNA)和信使RNA(mRNA)合成的调控外,还存在互补RNA(cRNA,即完整转录本)合成调控。