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初诊 17 年后软组织和肋骨移植物中复发性下颌骨成釉细胞瘤。

Recurrent mandibular ameloblastoma in soft tissue and rib graft 17 years after initial presentation.

机构信息

Surgical Oncology Unit, Oncology Center Mansoura University (OCMU), Mansoura, Egypt.

Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

出版信息

J Egypt Natl Canc Inst. 2020 Jan 6;32(1):1. doi: 10.1186/s43046-019-0012-1.

Abstract

BACKGROUND

Ameloblastoma is the commonest odontogenic tumour of epithelial origin with a high incidence for developing local recurrence. We present a patient who developed local recurrence in both soft tissue and bone graft 17 years after the initial presentation.

CASE PRESENTATION

A 75-year-old female with a previous history of right hemimandibulectomy and rib reconstruction for ameloblastoma in 1999 presented to our centre with a large cystic mouth floor swelling, biopsy from which revealed recurrent ameloblastoma. The patient underwent excision of the recurrent mass en bloc with the cystic swelling through oral and cervical approaches. The patient was discharged after 5 days with an uneventful postoperative course and with a free 2-year follow-up from further recurrence.

CONCLUSION

Ameloblastoma is a locally aggressive tumour for which wide local excision with adequate margins is the best management approach. Recurrence of ameloblastoma even after adequate resection is not uncommon, and its management is considered a surgical challenge. A very long time may pass between the initial presentation and the development of recurrence.

摘要

背景

成釉细胞瘤是最常见的牙源性上皮来源的肿瘤,局部复发的发生率很高。我们报告了 1 例患者,其在初次就诊后 17 年出现软组织和骨移植物局部复发。

病例介绍

一名 75 岁女性,1999 年曾因成釉细胞瘤行右侧下颌骨部分切除术和肋骨重建术,因口腔底部大囊性肿胀来我院就诊,活检显示为复发性成釉细胞瘤。通过口腔和颈部入路整块切除复发性肿块和囊性肿胀。患者术后 5 天出院,术后过程无并发症,2 年无进一步复发。

结论

成釉细胞瘤是一种局部侵袭性肿瘤,广泛局部切除加足够的切缘是最佳治疗方法。即使在充分切除后,成釉细胞瘤的复发也并不少见,其治疗被认为是一个手术挑战。初次就诊和复发之间可能会经过很长一段时间。

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