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下颌成釉细胞瘤中的严重高钙血症

Overwhelming hypercalcaemia in mandibular ameloblastoma.

作者信息

Lo Tom Edward Ngo, Villafuerte Cesar Vincent, Acampado Laura Trajano

机构信息

Department of Medicine-Endocrinology, University of the Philippines-Philippine General Hospital, Manila, Philippines.

Department of Otorhinolaryngology, University of the Philippines-Philippine General Hospital, Manila, Philippines.

出版信息

BMJ Case Rep. 2014 Oct 17;2014:bcr2014205491. doi: 10.1136/bcr-2014-205491.

Abstract

Ameloblastoma is considered to be a benign odontogenic tumour of epithelial in origin that is slow growing but recurrent and invasive in nature. Some of its features have been sources of debate among experts regarding its benign or malignant character. We report a case of a 20-year-old Filipino woman with right mandibular ameloblastoma presenting with overwhelming hypercalcaemia. Work ups for hypercalcaemia eventually revealed tumoral hypercalcaemia, which was initially controlled with intravenous bisphosphanate. The patient eventually underwent tumour excision and mandibular reconstruction, which totally corrected hypercalcaemia. This case will highlight the rare association of hypercalcaemia among patients with ameloblastoma.

摘要

成釉细胞瘤被认为是一种起源于上皮的良性牙源性肿瘤,生长缓慢,但具有复发性和侵袭性。其一些特征在专家中引发了关于其良性或恶性特征的争论。我们报告一例20岁菲律宾女性右下颌成釉细胞瘤患者,该患者出现严重高钙血症。对高钙血症的检查最终发现是肿瘤性高钙血症,最初通过静脉注射双膦酸盐进行控制。患者最终接受了肿瘤切除和下颌骨重建,高钙血症得到了完全纠正。该病例将凸显成釉细胞瘤患者中高钙血症这种罕见的关联。

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Overwhelming hypercalcaemia in mandibular ameloblastoma.下颌成釉细胞瘤中的严重高钙血症
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本文引用的文献

2
Unicystic mural ameloblastoma: an unusual case report.单囊性壁成釉细胞瘤:一份罕见病例报告。
Case Rep Dent. 2013;2013:957418. doi: 10.1155/2013/957418. Epub 2013 Apr 23.
3
Review of metastasizing (malignant) ameloblastoma (METAM): pattern of metastasis and treatment.转移性(恶性)成釉细胞瘤(METAM)综述:转移模式与治疗
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jun;111(6):734-41. doi: 10.1016/j.tripleo.2010.12.018. Epub 2011 Apr 1.
9
Parathyroid hormone-related protein (PTHrP) expression in ameloblastoma.成釉细胞瘤中甲状旁腺激素相关蛋白(PTHrP)的表达
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):208-19. doi: 10.1016/j.tripleo.2003.10.003.

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