Morales-Roselló José, Buongiorno Silvia, Loscalzo Gabriela, Scarinci Elisa, Giménez Roca Laura, Cañada Martínez Antonio José, Rosati Paolo, Lanzone Antonio, Perales Marín Alfredo
Servicio de Obstetricia, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain.
J Matern Fetal Neonatal Med. 2022 Apr;35(8):1419-1425. doi: 10.1080/14767058.2020.1755651. Epub 2020 May 6.
The aim of the study was to investigate the influence of ethnicity and cerebroplacental ratio (CPR) on the birth weight (BW) of first generation Indo-Pakistan immigrants' newborns.
This was a retrospective study in a mixed population of 620 term Caucasian and Indo-Pakistan pregnancies, evaluated in two reference hospitals of Spain and Italy. All fetuses underwent a scan and Doppler examination within two weeks of delivery. The influence of fetal gender, ethnicity, GA at delivery, CPR, maternal age, height, weight and parity on BW was evaluated by multivariable regression analysis.
Newborns of first generation Indo-Pakistan immigrants were smaller than local Caucasian newborns (mean BW mean= 3048 ± 435 g versus 3269 ± 437 g, < .001). Multivariable regression analysis demonstrated that all studied parameters, but maternal age and ethnicity, were significantly associated with BW. The most important were GA at delivery (partial = 0.175, < .001), CPR (partial = 0.032, < .001), and fetal gender (partial = 0,029, < .001).
The propensity to a lower BW, explained by placental dysfunction but not by maternal ethnicity is transmitted to newborns of first generation immigrants. Whatever are the factors implied they persist in the new residential setting.
本研究旨在调查种族和脑胎盘比率（CPR）对第一代印巴移民新生儿出生体重（BW）的影响。
这是一项对620例足月白种人和印巴孕妇的混合人群进行的回顾性研究，在西班牙和意大利的两家参考医院进行评估。所有胎儿在分娩后两周内接受扫描和多普勒检查。通过多变量回归分析评估胎儿性别、种族、分娩时的孕周、CPR、产妇年龄、身高、体重和产次对BW的影响。
第一代印巴移民的新生儿比当地白种人新生儿小（平均BW分别为3048±435克和3269±437克，P<0.001）。多变量回归分析表明，除产妇年龄和种族外，所有研究参数均与BW显著相关。最重要的是分娩时的孕周（偏回归系数=0.175，P<0.001）、CPR（偏回归系数=0.032，P<0.001）和胎儿性别（偏回归系数=0.029，P<0.001）。
低出生体重的倾向由胎盘功能障碍而非产妇种族所解释，这种倾向会传递给第一代移民的新生儿。无论涉及哪些因素，它们在新的居住环境中仍然存在。
