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HLA alleles associated with asparaginase hypersensitivity in childhood ALL: a report from the DFCI Consortium.与儿童 ALL 中门冬酰胺酶过敏相关的 HLA 等位基因：DFCI 联盟的报告。
Pharmacogenomics. 2020 Jun;21(8):541-547. doi: 10.2217/pgs-2019-0195. Epub 2020 May 6.
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HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia.HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 单体型与急性淋巴细胞白血病中门冬酰胺酶过敏反应的高风险相关。
Haematologica. 2017 Sep;102(9):1578-1586. doi: 10.3324/haematol.2017.168211. Epub 2017 Jun 8.
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Two tagging single-nucleotide polymorphisms to capture HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype associated with asparaginase hypersensitivity.两个标签单核苷酸多态性以捕获与门冬酰胺酶超敏反应相关的 HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 单倍型。
Br J Clin Pharmacol. 2021 Jun;87(6):2542-2548. doi: 10.1111/bcp.14664. Epub 2020 Dec 16.
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HLA-DRB1, -DQA1 and -DQB1 genotyping of 180 Czech individuals from the Czech Republic pop 3.对来自捷克共和国群体3的180名捷克个体进行HLA-DRB1、-DQA1和-DQB1基因分型。
Hum Immunol. 2016 Apr;77(4):365-6. doi: 10.1016/j.humimm.2016.02.003. Epub 2016 Feb 8.
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Association of HLA class II (DRB1, DQA1, DQB1) alleles and haplotypes with myasthenia gravis and its subgroups in the Iranian population.伊朗人群中HLA II类（DRB1、DQA1、DQB1）等位基因和单倍型与重症肌无力及其亚组的关联。
J Neurol Sci. 2015 Dec 15;359(1-2):335-42. doi: 10.1016/j.jns.2015.11.021. Epub 2015 Nov 12.
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Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype.埃及1型糖尿病儿童的风险基因与自身抗体——HLA-DRB1*04:05-DQA1*03-DQB1*02风险单倍型携带者中自身抗体的低频率
Diabetes Metab Res Rev. 2015 Mar;31(3):287-94. doi: 10.1002/dmrr.2609. Epub 2014 Nov 24.
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HLA-DRB1, -DQA1 and -DQB1 alleles and haplotypes in first-generation Pakistani immigrants in Norway.HLA-DRB1、-DQA1 和 -DQB1 等位基因和单倍型在挪威第一代巴基斯坦移民中。
Scand J Immunol. 2012 Apr;75(4):426-30. doi: 10.1111/j.1365-3083.2011.02669.x.
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HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chinese Han population.中国汉族人群中与大动脉炎相关的HLA - DQA1、DQB1和DRB1等位基因。
Hum Immunol. 2015 Apr;76(4):241-4. doi: 10.1016/j.humimm.2015.01.008. Epub 2015 Jan 27.
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Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran.伊朗地中海贫血患者中人类白细胞抗原 II 类等位基因与丙型肝炎病毒清除和持续感染的关联。
J Med Virol. 2015 Sep;87(9):1565-72. doi: 10.1002/jmv.24211. Epub 2015 May 12.
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Genetic association study of the HLA class II alleles DRB1, DQA1, and DQB1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis.与内侧海马硬化相关的药物抵抗性颞叶癫痫患者中HLA II类等位基因DRB1、DQA1和DQB1的基因关联研究。
Seizure. 2015 Sep;31:7-11. doi: 10.1016/j.seizure.2015.06.005. Epub 2015 Jul 2.
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Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences.深入了解天冬酰胺酶过敏反应：探索药物遗传学影响。
Pharmaceutics. 2024 Aug 28;16(9):1134. doi: 10.3390/pharmaceutics16091134.
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A Review of L-Asparaginase Hypersensitivity in Paediatric Acute Lymphoblastic Leukaemia Patients with Regard to the Measurement of Anti-Asparaginase Antibodies and Their Genetic Predisposition.关于抗天冬酰胺酶抗体检测及其遗传易感性的小儿急性淋巴细胞白血病患者中天冬酰胺酶超敏反应的综述
Malays J Med Sci. 2023 Oct;30(5):40-51. doi: 10.21315/mjms2023.30.5.4. Epub 2023 Oct 30.
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Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.II 类人类白细胞抗原变异与培门冬酶过敏风险相关。
Clin Pharmacol Ther. 2021 Sep;110(3):794-802. doi: 10.1002/cpt.2241. Epub 2021 Apr 21.
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Two tagging single-nucleotide polymorphisms to capture HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype associated with asparaginase hypersensitivity.两个标签单核苷酸多态性以捕获与门冬酰胺酶超敏反应相关的 HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 单倍型。
Br J Clin Pharmacol. 2021 Jun;87(6):2542-2548. doi: 10.1111/bcp.14664. Epub 2020 Dec 16.
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Pharmacogenomics as a Tool to Limit Acute and Long-Term Adverse Effects of Chemotherapeutics: An Update in Pediatric Oncology.药物基因组学作为限制化疗药物急性和长期不良反应的工具：儿科肿瘤学的最新进展
Front Pharmacol. 2020 Aug 5;11:1184. doi: 10.3389/fphar.2020.01184. eCollection 2020.
本文引用的文献
1
Influence of genetic factors on long-term treatment related neurocognitive complications, and on anxiety and depression in survivors of childhood acute lymphoblastic leukemia: The Petale study.遗传因素对儿童急性淋巴细胞白血病幸存者长期治疗相关神经认知并发症、焦虑和抑郁的影响：Petale 研究。
PLoS One. 2019 Jun 10;14(6):e0217314. doi: 10.1371/journal.pone.0217314. eCollection 2019.
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Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008.根据北欧小儿肿瘤协作组 ALL2008 方案治疗的儿童对 PEG-天冬酰胺酶过敏的遗传易感性。
Br J Haematol. 2019 Feb;184(3):405-417. doi: 10.1111/bjh.15660. Epub 2018 Nov 18.
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Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII.在小鼠中，对天冬酰胺酶的过敏反应是由抗天冬酰胺酶 IgE 和 IgG 以及免疫球蛋白受体 FcεRI 和 FcγRIII 介导的。
Haematologica. 2019 Feb;104(2):319-329. doi: 10.3324/haematol.2018.199448. Epub 2018 Sep 20.
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HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia.HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 单体型与急性淋巴细胞白血病中门冬酰胺酶过敏反应的高风险相关。
Haematologica. 2017 Sep;102(9):1578-1586. doi: 10.3324/haematol.2017.168211. Epub 2017 Jun 8.
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Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.全外显子组测序确定了儿童急性淋巴细胞白血病患者中天冬酰胺酶相关并发症的遗传危险因素。
Oncotarget. 2017 Jul 4;8(27):43752-43767. doi: 10.18632/oncotarget.17959.
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L-asparaginase in the treatment of patients with acute lymphoblastic leukemia.L-天冬酰胺酶治疗急性淋巴细胞白血病患者
J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):62-71. doi: 10.4103/0976-500X.184769.
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Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation.天冬酰胺酶超敏反应和沉默失活识别与管理的专家共识建议
Haematologica. 2016 Mar;101(3):279-85. doi: 10.3324/haematol.2015.137380.
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Current perspective on pediatric pharmacogenomics.
Expert Opin Drug Metab Toxicol. 2016;12(4):363-5. doi: 10.1517/17425255.2016.1145656. Epub 2016 Feb 15.
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Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity.儿童急性淋巴细胞白血病亚组在天冬酰胺酶超敏反应的遗传易感性方面可能存在显著差异。
PLoS One. 2015 Oct 12;10(10):e0140136. doi: 10.1371/journal.pone.0140136. eCollection 2015.
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Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes.一例罕见的家族性儿童急性淋巴细胞白血病的全外显子组测序揭示了范可尼贫血基因中可能的易感突变。
BMC Cancer. 2015 Jul 23;15:539. doi: 10.1186/s12885-015-1549-6.
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