Hoen B, Renoult E, Jonon B, Kessler M
Department of Nephrology, Hôpital de Brabois, CHRU de Nancy, Vandoeuvre-lès-Nancy, France.
Nephron. 1988;50(4):378-9. doi: 10.1159/000185208.
A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of infection on physical examination. All blood cultures yielded Yersinia enterocolitica. The aim of this case report is to recall the potential risk of Yersinia sepsis in iron overload patients treated with desferrioxamine, even for a short time. The diagnosis should be suspected even in the absence of digestive symptoms, leading to immediate desferrioxamine withdrawal and antibiotic therapy.
一名长期接受血液透析的男性患者因定期输血而存在全身性铁过载。由于怀疑他有铝过载,他接受了一次去铁胺静脉注射(这支持了该假设)。四天后,他出现高热,体格检查未发现感染灶。所有血培养均检出小肠结肠炎耶尔森菌。本病例报告的目的是提醒大家,即使是短期接受去铁胺治疗的铁过载患者,也存在耶尔森菌败血症的潜在风险。即使没有消化系统症状,也应怀疑该诊断,从而立即停用去铁胺并进行抗生素治疗。