Foster Catherine, Steventon Jessica J, Helme Daniel, Tomassini Valentina, Wise Richard G
Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
Cardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom.
Front Physiol. 2020 Apr 21;11:360. doi: 10.3389/fphys.2020.00360. eCollection 2020.
This cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. Gray matter cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were quantified in a sample of young adults within a normal fitness range. Based on existing Transcranial Doppler ultrasound and fMRI evidence, we predicted a positive relationship between fitness and resting gray matter CBF and CVR. Exploratory hypotheses that higher Opeak would be associated with higher GM volume and cognitive performance were also investigated. 20 adults underwent a Opeak test and a battery of cognitive tests. All subjects also underwent an MRI scan where multiple inversion time (MTI) pulsed arterial spin labeling (PASL) was used to quantify resting CBF and CVR to 5% CO. Region of interest analysis showed a non-significant inverse correlation between whole-brain gray matter CBF and Opeak; = -0.4, = 0.08, corrected (') = 0.16 and a significant positive correlation between Opeak and whole-brain averaged gray matter CVR; = 0.62, = 0.003, ' = 0.006. Voxel-wise analysis revealed a significant inverse association between Opeak and resting CBF in the left and right thalamus, brainstem, right lateral occipital cortex, left intra-calcarine cortex and cerebellum. The results of this study suggest that aerobic fitness is associated with lower baseline CBF and greater CVR in young adults.
这项横断面研究调查了有氧适能对健康大脑脑血管功能的影响。在正常适能范围内的年轻成年人样本中，对灰质脑血流量（CBF）和脑血管反应性（CVR）进行了量化。基于现有的经颅多普勒超声和功能磁共振成像证据，我们预测适能与静息灰质CBF和CVR之间存在正相关关系。还研究了探索性假设，即较高的Opeak与较高的灰质体积和认知表现相关。20名成年人接受了Opeak测试和一系列认知测试。所有受试者还接受了磁共振成像扫描，其中使用多反转时间（MTI）脉冲动脉自旋标记（PASL）来量化静息CBF和对5%二氧化碳的CVR。感兴趣区域分析显示，全脑灰质CBF与Opeak之间存在非显著的负相关；r = -0.4，p = 0.08，校正后p（FDR） = 0.16，且Opeak与全脑平均灰质CVR之间存在显著正相关；r = 0.62，p = 0.003，FDR = 0.006。体素分析显示，Opeak与左、右丘脑、脑干、右侧枕叶外侧皮质、左侧距状沟内皮质和小脑的静息CBF之间存在显著负相关。这项研究的结果表明，有氧适能与年轻成年人较低的基线CBF和较高的CVR相关。
