Department of Chemistry University of Pavia Viale Taramelli 12 27100 - Pavia Italy.
Department of System Medicine University of Rome Tor Vergata Via Montpellier 1 00133 - Rome Italy.
ChemistryOpen. 2020 Mar 24;9(5):519-528. doi: 10.1002/open.202000034. eCollection 2020 May.
Two new families of -nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.
两种新型的 -核苷类似物家族通过与烯丙醇的亚硝羰烯反应引入蒽部分得到了制备。核心结构是异恶唑烷杂环，在 C3 碳上引入一个苯基环或二甲基部分。不同的杂碱基被插入到杂环的 5 位。其中一种合成化合物表现出良好的诱导细胞死亡能力，并且在处理的细胞中可以观察到明显的核碎裂。
