Badran Eman F, Jadcherla Sudarshan
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, 11942, Jordan.
Divisions of Neonatology, Pediatric Gastroenterology and Nutrition, Nationwide Childrens' Hospital and The Ohio State University College of Medicine, Columbus, OH, 43215, USA.
Int J Pediatr Adolesc Med. 2020 Mar;7(1):26-30. doi: 10.1016/j.ijpam.2020.03.001. Epub 2020 Mar 5.
Gastroesophageal reflux (GER) can be a normal physiological process, or can be bothersome, when aerodigestive consequences are associated; the latter is often interpreted as GER disease (GERD). However, the distinction between these two entities remains an enigma among infants surviving after neonatal intensive care (NICU) care. Symptoms related to GERD are heterogeneous, and are often managed with changes in diet, feeding methods, and acid suppressive therapy. However, none of these approaches have been well-tested in neonates; hence practice variation is very high world-wide. In this paper, we explain the variation in diagnosis, pathophysiology of the clinical presentation, and highlight approaches to diagnosis and management.
胃食管反流（GER）可以是一种正常的生理过程，或者当与气消化道后果相关时，可能会令人烦恼；后者通常被解释为胃食管反流病（GERD）。然而，在新生儿重症监护（NICU）护理后存活的婴儿中，这两种情况之间的区别仍然是个谜。与GERD相关的症状多种多样，通常通过改变饮食、喂养方法和抑酸治疗来处理。然而，这些方法在新生儿中都没有得到充分测试；因此，全球范围内的实践差异非常大。在本文中，我们解释了诊断的差异、临床表现的病理生理学，并强调了诊断和管理方法。
