子宫内膜炎患者子宫内膜异位症风险增加-一项涉及 84150 人的全国性队列研究。

Increased risk of endometriosis in patients with endometritis - a nationwide cohort study involving 84,150 individuals.

机构信息

Department of Obstetrics and Gynecology, Women and Children's Health, Royal North Shore Hospital, Sydney, NSW, Australia.

School of Medicine, China Medical University, Taichung, Taiwan.

出版信息

Ginekol Pol. 2020;91(4):193-200. doi: 10.5603/GP.2020.0040.

DOI:10.5603/GP.2020.0040

PMID:32374019

Abstract

OBJECTIVES

To evaluate the incidence of endometriosis among endometritis patients and its association with confounding comorbidities.

MATERIAL AND METHODS

A population-based, retrospective cohort study of women aged between 20 to 55 years, who were newly diagnosed with endometritis between 2000 to 2013. A total of 16,830 endometritis patients and 67,230 non-endometritis individuals were enrolled by accessing data from the National Health Insurance Research Database of Taiwan. The comorbidities accessed were uterine leiomyoma, rheumatoid arthritis, ovarian cancer, infertility and allergic diseases.

RESULTS

The mean follow-up period was 9.15 years for the non-endometritis cohort and 9.13 years for the endometritis cohort. There were significantly higher percentages of uterine leiomyoma, rheumatoid arthritis, infertility, ovarian cancer and allergic diseases in the endometritis cohort than in the non-endometritis cohort. Patients with endometritis had a 1.5-fold increased risk of their condition advancing to endometriosis (HR 1.58, 95% CI 1.48-1.68).

CONCLUSIONS

Our results suggest that patients with endometritis exhibited a positive correlation in developing endometriosis.

摘要

目的

评估子宫内膜炎患者中子宫内膜异位症的发生率及其与混杂合并症的关系。

材料与方法

这是一项基于人群的回顾性队列研究，纳入了 2000 年至 2013 年间新诊断为子宫内膜炎的 20 至 55 岁女性。通过访问来自中国台湾国民健康保险研究数据库的数据，共纳入了 16830 例子宫内膜炎患者和 67230 例非子宫内膜炎患者。所纳入的合并症包括子宫肌瘤、类风湿性关节炎、卵巢癌、不孕和过敏性疾病。

结果

非子宫内膜炎队列的平均随访期为 9.15 年，子宫内膜炎队列的平均随访期为 9.13 年。与非子宫内膜炎队列相比，子宫内膜炎队列中子宫肌瘤、类风湿性关节炎、不孕、卵巢癌和过敏性疾病的比例明显更高。患有子宫内膜炎的患者其病情进展为子宫内膜异位症的风险增加了 1.5 倍（HR 1.58，95%CI 1.48-1.68）。