Efe Süleyman Cagan, Gurbuz Ahmet Seyfettin, Ozturk Semi, Demir Kadir
Department of Cardiology, Istanbul Education and Research Hospital, Istanbul, Turkey.
Department of Cardiology, Necmettin Erbakan University, Konya, Turkey.
J Clin Ultrasound. 2020 Jul;48(6):324-329. doi: 10.1002/jcu.22849. Epub 2020 May 6.
Although the hepatic and neurological consequences of Wilson's disease (WD) have been investigated in detail, its cardiac involvement remains little studied. Our aim was to investigate potential cardiac differences in strain (ST) and strain rate (STR) echocardiography in adult WD patients compared with controls.
We included 30 patients with WD and a control group of 26 sex and age matched healthy adults. None of the subjects in either group had cardiac complaint. WD patients were clinically evaluated by a neurologist and undergone cranial magnetic resonance imaging. They were then divided into two groups according to the presence (NW) or absence (non-NW) of neurological involvement. Standard and advanced speckle tracking echocardiographic evaluations were performed in each group according to guidelines.
Left ventricular (LV) systolic and diastolic diameters and wall thickness measurements were within normal limits and did not differ significantly between the groups (P > .05). Neither atrial peak longitudinal and circumferential ST variables nor LV global and longitudinal ST and STR variables showed significant differences between the NW, the non-NW, and the control group (P > .05).
Our echocardiographic study showed no detectable difference between adult WD patients with or without neurological involvement and healthy subjects.
尽管威尔逊病（WD）的肝脏和神经学后果已得到详细研究，但其心脏受累情况仍研究较少。我们的目的是研究成年WD患者与对照组在应变（ST）和应变率（STR）超声心动图方面的潜在心脏差异。
我们纳入了30例WD患者和一个由26名性别和年龄匹配的健康成年人组成的对照组。两组中的受试者均无心脏不适。WD患者由神经科医生进行临床评估，并接受头颅磁共振成像检查。然后根据是否存在神经受累情况将他们分为两组（有神经受累组[NW]和无神经受累组[非NW]）。每组均按照指南进行标准和高级斑点追踪超声心动图评估。
左心室（LV）的收缩和舒张直径以及壁厚度测量值均在正常范围内，两组之间无显著差异（P > 0.05）。NW组、非NW组和对照组之间，无论是心房纵向和圆周方向的峰值ST变量，还是LV整体及纵向的ST和STR变量，均无显著差异（P > 0.05）。
我们的超声心动图研究表明，有或无神经受累的成年WD患者与健康受试者之间未发现可检测到的差异。
