Canciani M, Barlocco E G, Mastella G, de Santi M M, Gardi C, Lungarella G
Pediatric Pulmonology and Cystic Fibrosis Center, Verona, Italy.
Pediatr Pulmonol. 1988;5(4):210-4. doi: 10.1002/ppul.1950050406.
In order to evaluate the clinical value of the saccharin test as a practical and simple measure of mucociliary clearance, nasal mucociliary clearance (NMCC) and ciliary ultrastructure were studied in 22 patients suspected of having primary ciliary dyskinesia (PCD) based on the saccharin test. Ten patients fulfilling the diagnostic criteria of PCD had a pathological response to the saccharin test (transport time greater than 60 minutes), and this was consistently associated with ultrastructural defects, specific for PCD. These results validate the suitability of the clinical use of the saccharin test as a screening procedure for NMCC. The false-negative results obtained in three cases of PCD, all with borderline values, cannot be ascribed to ineffectiveness of the test, but rather to the persistence of some motility by certain defective cilia, detectable by microphoto-oscillographic investigation of specimens obtained by nasal biopsy or brushing.
为了评估糖精试验作为一种实用且简单的黏液纤毛清除功能检测方法的临床价值，我们基于糖精试验对22例疑似原发性纤毛运动障碍（PCD）的患者进行了鼻黏液纤毛清除功能（NMCC）和纤毛超微结构研究。10例符合PCD诊断标准的患者对糖精试验呈现病理性反应（转运时间大于60分钟），且这与PCD特有的超微结构缺陷始终相关。这些结果证实了糖精试验作为NMCC筛查程序临床应用的适用性。在3例PCD患者中获得的假阴性结果，均处于临界值，不能归因于试验无效，而是某些有缺陷的纤毛仍存在一定的运动能力，这可通过对经鼻活检或刷检获取的标本进行显微光振荡描记研究检测到。
