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抗肥胖药物的安全性审查是否应适用于其他慢性用药?

Should the Same Safety Scrutiny of Antiobesity Medications be Applied to Other Chronic Usage Drugs?

机构信息

Obesity Group, Department of Endocrinology, Hospital das Clinicas Universidade de São Paulo, São Paulo, Brazil.

Department of Epidemiology and Prevention, Brazilian Association for the Study of Obesity (ABESO), Sao Paulo, Brazil.

出版信息

Obesity (Silver Spring). 2020 Jul;28(7):1171-1172. doi: 10.1002/oby.22810. Epub 2020 May 6.

Abstract

Obesity treatment is highly stigmatized, mainly because of the stigma of obesity itself. The frequent withdrawal of medications, lorcaserin being the last example, contributes to this stigma, but it is also probably a reflection of it, as data suggest that the threshold for a withdrawal is lower than with other classes of drugs. Safety should always be an absolute priority for every new medication, especially when used on a chronic basis; however, the safety scrutiny given to antiobesity medications is not given for other medications, such as postmenopausal hormone therapy and central nervous system drugs for psychiatric use. The withdrawal of medications for obesity can also impact future research in the area, so we need transparency and equality. Transparency in knowing exactly what reason led to a drug being discontinued and equality in long-term safety should be a concern with any medication prescribed for chronic diseases.

摘要

肥胖症的治疗受到高度污名化,主要是因为肥胖本身的污名化。药物经常被撤市,洛卡塞嗪就是最近的一个例子,这加剧了这种污名化,但这也可能反映了这种污名化,因为数据表明,撤市的门槛低于其他类别的药物。对于每一种新药,安全性都应该始终是绝对优先考虑的,尤其是在长期使用的情况下;然而,对于抗肥胖药物的安全性审查并没有给予其他药物,如绝经后激素治疗和用于精神科的中枢神经系统药物。抗肥胖药物的撤市也可能会影响该领域的未来研究,因此我们需要透明度和平等性。对于任何用于治疗慢性疾病的药物,都应该透明地了解导致药物撤市的确切原因,并平等关注长期安全性。

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