Gragnoli G, Postorino G, Tanganelli I, Brandi L
Minerva Med. 1977 Apr 21;68(19):1281-92.
The plasma lipid picture before, during and after 4 months of administering p-chloro-phenoxy-alpha-isobutyrrate of 3-hydroxy-methylpyridine hydrochloride (Nicofibrate) in a group of diabetics was studied. Treatment led to a significant reduction in plasma cholesterol and triglycerides and brought the lipoprotein picture back within the norm. Nicofibrate did not lead to significant increases in uricaemia nor to any worsening in carbohydrate tolerance. At the doses used, a significant drop in plasma prothrombinic activity was encountered, while no noteworthy variations were observed in the other biohumoral parameters examined. In the light of these results, the various aetiopathogenetic aspects of the hyperlipaemia so frequently observed in diabetes mellitus are discussed.
对一组糖尿病患者在服用对氯苯氧异丁酸 3 - 羟甲基吡啶盐酸盐（诺衡）前、服药期间及服药 4 个月后的血脂情况进行了研究。治疗导致血浆胆固醇和甘油三酯显著降低，并使脂蛋白情况恢复到正常范围内。诺衡未导致尿酸血症显著升高，也未使糖耐量恶化。在所使用的剂量下，血浆凝血酶原活性显著下降，而在所检查的其他生物体液参数中未观察到值得注意的变化。根据这些结果，对糖尿病中经常观察到的高脂血症的各种病因发病机制方面进行了讨论。
