Trouillas J, Girod C, Loras B, Claustrat B, Sassolas G, Perrin G, Buonaguidi R
Laboratoire d'Histologie, Faculté de Médecine Alexis Carrel, Lyon, France.
Pathol Res Pract. 1988 Sep;183(5):596-600. doi: 10.1016/S0344-0338(88)80019-0.
TSH secretion by a pituitary tumor is very rare (2%) and it is often associated with another hormone: GH or PRL essentially. We present here nine tumors in which the TSH secretion was proved by immunocytochemistry (ICC) and by RIA in the tumor extracts, in the serum and in the culture medium. Four tumors secreted TSH only. Five tumors secreted TSH and GH predominantly. In 3 of them traces of other hormones (PRL and FSH) were also detected. The "pure" TSH adenomas were monomorphous with typical ultrastructural and immunocytochemical features. Plurihormonal TSH adenomas were bimorphous with different cells secreting GH and TSH or monomorphous with one type of cell which secreted TSH or GH or both TSH and GH. In a majority of the cases, the tumoral TSH secretion induced hyperthyroidism but in 2 patients with TSH adenoma there was euthyroidism and in another with TSH-GH adenoma there was no sign of acromegaly and GH serum levels were normal.
垂体瘤分泌促甲状腺激素（TSH）的情况非常罕见（2%），且常与另一种激素相关：主要是生长激素（GH）或催乳素（PRL）。我们在此呈现9例肿瘤，其TSH分泌通过免疫细胞化学（ICC）以及肿瘤提取物、血清和培养基中的放射免疫分析（RIA）得以证实。4例肿瘤仅分泌TSH。5例肿瘤主要分泌TSH和GH。其中3例还检测到微量其他激素（PRL和FSH）。“纯”TSH腺瘤形态单一，具有典型的超微结构和免疫细胞化学特征。多激素TSH腺瘤则形态双相，有不同细胞分别分泌GH和TSH，或者形态单相，由一种细胞分泌TSH或GH或同时分泌TSH和GH。在大多数病例中，肿瘤性TSH分泌导致甲状腺功能亢进，但2例TSH腺瘤患者甲状腺功能正常，另1例TSH - GH腺瘤患者无肢端肥大症迹象且血清GH水平正常。
