Kanarkowski R, Wankiewicz G, Lehmann W, Rybakowski J
Department of Psychiatry, Medical Academy, Bydgoszcz, Poland.
Pol J Pharmacol Pharm. 1988 Jan-Feb;40(1):55-61.
Plasma levels of carbamazepine (CBZ) were studied in 10 patients with psychiatric illnesses who were given the drug every 12 hours for 28 days. No correlation has been found between the daily dose of carbamazepine (calculated for body weight) and the steady-state level of the drug. In most patients taking CBZ as the only drug, a 10-20% fall in plasma drug level occurred between the first and second week of treatment, suggesting autoinduction process. A significant correlation was obtained between the plasma level of CBZ measured after the first dose of the drug and the subsequent steady state concentration. This makes possible to predict the steady-state CBZ concentration early in the treatment.
对10名患有精神疾病的患者进行了研究，这些患者每12小时服用一次卡马西平（CBZ），持续28天。未发现卡马西平的每日剂量（按体重计算）与药物的稳态水平之间存在相关性。在大多数仅服用CBZ的患者中，治疗的第一周和第二周之间血浆药物水平下降了10 - 20%，提示存在自身诱导过程。首次给药后测得的CBZ血浆水平与随后的稳态浓度之间存在显著相关性。这使得在治疗早期预测CBZ的稳态浓度成为可能。
