阿霉素及其类似物——表阿霉素对家兔循环系统的急性作用。
The acute effect of doxorubicin and its analogue--4'-epidoxorubicin on circulatory system in rabbits.
作者信息
Drzewoski J, Polakowski P, Kaszubski P, Orszulak-Michalak D
机构信息
Department of Pharmacology, Medical Academy, Lódź, Poland.
出版信息
Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):159-65.
PMID:3237565
Abstract
The acute influence of doxorubicin (DXR) and its analogue - 4'-epidoxorubicin (4'-epiDXR) on cardiovascular system in rabbits was compared. A single intravenous dose of DXR (1 and 3 mg/kg) did not affect the cardiac index, stroke index and heart rate, but reduced the mean arterial blood pressure and total peripheral resistance. In contrast, 4-epiDXR, in the same doses, did not affect any of the hemodynamic parameters.
摘要
比较了阿霉素（DXR）及其类似物4'-表阿霉素（4'-epiDXR）对兔心血管系统的急性影响。单次静脉注射剂量为1和3mg/kg的DXR不影响心脏指数、每搏指数和心率，但会降低平均动脉血压和总外周阻力。相比之下，相同剂量的4'-epiDXR对任何血流动力学参数均无影响。
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