Newman W P, Guzman M A, Strong J P, Tracy R E, Oalmann M C
Department of Pathology, LSU Medical Center, New Orleans.
Mod Pathol. 1988 Mar;1(2):109-13.
The extent and prevalence of atherosclerotic lesions in the coronary arteries and aortas of deceased 25 to 44-yr-old men, autopsied in New Orleans during two different time periods (1960-64 and 1969-78), were evaluated to determine if changes in lesions had occurred in parallel with reported decreases in coronary heart disease death rates. Results of these evaluations showed that both the extent and prevalence of raised atherosclerotic lesions were significantly less in the coronary arteries of white men in the second time period. No significant difference was detected in black men. In the aorta there were no significant differences between studies in whites, but in blacks, there were significantly more extensive raised lesions in the second time period. These findings strongly suggest that the extent of involvement with atherosclerotic lesions in a given population may change over time. The underlying mechanisms responsible for these secular trends in atherosclerosis merit additional study.
对在新奥尔良两个不同时间段（1960 - 1964年和1969 - 1978年）进行尸检的25至44岁男性死者的冠状动脉和主动脉中的动脉粥样硬化病变程度及患病率进行了评估，以确定病变的变化是否与报道的冠心病死亡率下降同步。这些评估结果表明，在第二个时间段，白人男性冠状动脉中动脉粥样硬化病变隆起的程度和患病率均显著降低。黑人男性中未检测到显著差异。在主动脉中，白人的研究之间没有显著差异，但在黑人中，第二个时间段有更广泛的隆起病变。这些发现有力地表明，特定人群中动脉粥样硬化病变的累及程度可能随时间变化。导致动脉粥样硬化这些长期趋势的潜在机制值得进一步研究。
