Department of Biomedical Engineering, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, South Korea.
Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, South Korea.
Sci Rep. 2020 May 6;10(1):7643. doi: 10.1038/s41598-020-64641-w.
Restless legs syndrome (RLS) is a neurological disorder which is most commonly identified by an urge to move the legs. It often shows alterations in sensory processing which implies the salience network (SN) is experiencing changes. This study investigates the functional connectivity (FC) between the SN and other areas of the brain in RLS patients during the resting state period.
Thirty patients with drug naïve idiopathic RLS and 30 healthy age and gender matched controls were included in this study. Resting state fMRIs were performed in the morning during the asymptomatic period. The SN comparisons were conducted between the two groups.
The RLS group showed a reduction in SN FC in the right pyramis, and an increase in SN FC in the bilateral orbitofrontal gyri and right postcentral gyrus.
The results of this study give reason to believe that SN FC in RLS patients is altered during asymptomatic periods. This could have an influence on the processing of the saliency of information, particularly sensory information processing and inhibition mechanisms.
不宁腿综合征（RLS）是一种神经系统疾病，最常见的表现是腿部有移动的冲动。它通常表现出感觉处理的改变，这意味着突显网络（SN）正在经历变化。本研究在静息状态下，探讨 RLS 患者 SN 与大脑其他区域之间的功能连接（FC）。
本研究纳入了 30 名未经药物治疗的特发性 RLS 患者和 30 名年龄和性别匹配的健康对照组。在无症状期的上午进行静息态 fMRI 检查。对两组进行 SN 比较。
RLS 组显示右侧锥体 SN FC 降低，双侧眶额回和右侧中央后回 SN FC 增加。
本研究结果表明，RLS 患者在无症状期 SN FC 发生改变。这可能会影响信息突显的处理，特别是感觉信息处理和抑制机制。
