Dissolution of metronidazole from oral and vaginal dosage forms in sink and non-sink conditions.

The pharmaceutical availability of metronidazole from several commercial oral and vaginal dosage forms in sink and non-sink conditions has been examined by measuring the rate of drug dissolution. The results were interpreted by means of reversible and irreversible dissolution models. For non-sink conditions the reversible model was found to better interpret the data. The values of the relative dissolution rate constant, theoretical dissolution time and dissolution efficiency were obtained and discussed.