在评估炎症性肠病的疾病活动中，肝细胞生长因子和转化生长因子-β1 水平的临床意义。
Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease.
机构信息
Clinical Science Department, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Internal Medicine Department, Endocrinology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
出版信息
Can J Gastroenterol Hepatol. 2020 Apr 25;2020:2104314. doi: 10.1155/2020/2104314. eCollection 2020.
. Transforming growth factor-beta (TGF-) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses. They have been linked to inflammatory bowel diseases (IBD). In this study, we aim to assess the levels of TGF- and HGF and other inflammatory markers in patients with IBD and correlate them with the disease activity. . A cross-sectional study involving 100 patients with ulcerative colitis (UC) and 100 patients with Crohn's disease (CD) and 50 control subjects. TGF- and HGF levels were measured and correlated with disease activity. . Serum levels of TGF- and HGF were significantly higher in IBD patients compared with the control group. In the UC group, the levels of HGF and TGF- were significantly higher than in the CD group. Levels of TGF- and HGF correlate with the activity of IBD.
. 转化生长因子-β（TGF-）和肝细胞生长因子（HGF）是炎症细胞因子，作为免疫稳态和炎症反应的关键调节剂。它们与炎症性肠病（IBD）有关。在这项研究中，我们旨在评估 IBD 患者的 TGF-和 HGF 水平以及其他炎症标志物，并将其与疾病活动度相关联。. 一项涉及 100 例溃疡性结肠炎（UC）患者、100 例克罗恩病（CD）患者和 50 名对照者的横断面研究。测量了 TGF-和 HGF 水平，并与疾病活动度相关联。. 与对照组相比，IBD 患者的血清 TGF-和 HGF 水平明显升高。在 UC 组中，HGF 和 TGF-的水平明显高于 CD 组。TGF-和 HGF 水平与 IBD 的活动度相关。
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