Häuser Winfried, Klose Petra, Welsch Patrick, Petzke Frank, Nothacker Monika
Schmerzmedizin und Seelische Gesundheit, Medizinisches Versorgungszentrum Saarbrücken St. Johann, Großherzog-Friedrich-Straße 44-46, 66111, Saarbrücken, Deutschland.
Innere Medizin 1, Klinikum Saarbrücken, Saarbrücken, Deutschland.
Schmerz. 2020 Jun;34(3):245-278. doi: 10.1007/s00482-020-00471-z.
The update of the German S3 guidelines on long-term opioid therapy of chronic noncancer pain (CNCP), the LONTS (AWMF registration number 145/003), was scheduled for February 2020 due to the expiry of the validity period.
The guidelines were updated by 28 scientific societies and 2 patient self-help organizations under the coordination of the German Pain Society and the Association of the Scientific Medical Societies in Germany (AWMF).
A systematic literature search was performed in the CENTRAL, MEDLINE and Scopus databases from October 2013 to December 2018. The previous meta-analyses of randomized controlled trials (RCT) of opioids in CNPC syndromes with a study duration of ≥4 weeks were updated. Levels of evidence were assigned according to the Oxford Centre for Evidence-Based Medicine version 2009 classification system. The formulation and strength of recommendations was established in a multistep formalized consensus procedure, in accordance with AWMF rules and standards. The guidelines were reviewed by four experts not involved in the development of the guidelines. The public was given the opportunity to comment on the guidelines. The guidelines were approved by the executive boards of the societies that were engaged in development of the guidelines.
The guidelines will be published in several forms: complete and short scientific versions as well as clinical practice and patient versions.
由于有效期到期，德国关于慢性非癌性疼痛（CNCP）长期阿片类药物治疗的S3指南（LONTS，AWMF注册号145/003）更新计划于2020年2月进行。
在德国疼痛学会和德国科学医学协会联合会（AWMF）的协调下，由28个科学协会和2个患者自助组织对该指南进行了更新。
于2013年10月至2018年12月在CENTRAL、MEDLINE和Scopus数据库中进行了系统的文献检索。对先前关于阿片类药物在持续时间≥4周的CNPC综合征中的随机对照试验（RCT）的荟萃分析进行了更新。根据2009年版牛津循证医学中心分类系统确定证据水平。按照AWMF规则和标准，通过多步骤形式化共识程序确定建议的制定和力度。由4名未参与指南制定的专家对指南进行了评审。公众有机会对指南发表意见。指南获得了参与指南制定的协会执行委员会的批准。
该指南将以多种形式发布：完整和简短的科学版本以及临床实践和患者版本。
