Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1, Louvain-la-Neuve, 1348, Belgium.
Van''t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, The Netherlands.
Chemistry. 2020 Sep 16;26(52):11960-11965. doi: 10.1002/chem.202001399. Epub 2020 Aug 17.
Non-covalent interactions are important for directing protein folding across multiple intermediates and can even provide access to multiple stable structures with different properties and functions. Herein, we describe an approach for mimicking this behavior in the self-assembly of metal-organic cages. Two ligands, the bend angles of which are controlled by non-covalent interactions and one ligand lacking the above-mentioned interactions, were synthesized and used for self-assembly with Pd . As these weak interactions are easily broken, the bend angles have a controlled flexibility giving access to M (L1) , M (L2) , and M (L2) cages. By controlling the self-assembly conditions this process can be directed in a stepwise fashion. Additionally, the multiple endohedral hydrogen-bonding sites on the ligand were found to play a role in the binding and discrimination of neutral guests.
非共价相互作用对于指导蛋白质跨越多个中间体的折叠非常重要，甚至可以提供具有不同性质和功能的多个稳定结构的途径。在此，我们描述了一种在金属有机笼的自组装中模拟这种行为的方法。合成了两种配体，它们的弯曲角度受非共价相互作用的控制，其中一种配体缺乏上述相互作用，并用其与 Pd 进行自组装。由于这些弱相互作用很容易被打破，因此弯曲角度具有可控的灵活性，可以得到 M(L1)、M(L2)和 M(L2)笼。通过控制自组装条件，可以逐步指导这个过程。此外，配体上的多个内合氢键结合位点在中性客体的结合和识别中发挥作用。
