白血病患者自杀死亡的发生率和社会学风险因素：一项基于人群的研究。
Incidence of and sociological risk factors for suicide death in patients with leukemia: A population-based study.
机构信息
Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangdong Province, China.
School of Public Health, Xi'an Jiaotong University Health Science Center, Shaanxi Province, China.
出版信息
J Int Med Res. 2020 May;48(5):300060520922463. doi: 10.1177/0300060520922463.
OBJECTIVES
Suicide is closely related to sociological factors, but sociological analyses of suicide risk in leukemia are lacking. This study is the first to use the Surveillance, Epidemiology, and End Results Program (SEER) database to analyze sociological risk factors for suicide death in leukemia patients.
METHODS
A retrospective search of the SEER database was conducted. Logistic regression was used to identify independent risk factors for suicide death. Variables significant in the univariate logistic regression models were subsequently analyzed using multivariate regression.
RESULTS
The death rate was highest in California (1.73%). Suicide mortality was more common during the 1970s and 1980s, after which it trended downward. Young age at diagnosis (18-34 vs. >64 years: odds ratio [OR] = 1.537, 95% confidence interval [CI] = 1.007-2.347; 35-64 vs. >64 years: OR = 1.610, 95% CI = 1.309-1.979), being male (OR = 1.518, 95% CI = 1.230-1.873), and living where a high proportion of people have at least a bachelor's degree (>50% vs. <20%: OR = 8.115, 95% CI = 5.053-13.034) significantly increased suicide death risk.
CONCLUSION
Our findings could increase clinician awareness of and appropriate support for leukemia patients at risk of death by suicide.
目的
自杀与社会学因素密切相关，但针对白血病自杀风险的社会学分析尚不多见。本研究首次利用监测、流行病学和最终结果（SEER）数据库分析白血病患者自杀死亡的社会学危险因素。
方法
对 SEER 数据库进行回顾性检索。采用逻辑回归分析确定自杀死亡的独立危险因素。随后，对单变量逻辑回归模型中具有统计学意义的变量进行多变量回归分析。
结果
加利福尼亚州的死亡率最高（1.73%）。自杀死亡率在 20 世纪 70 年代和 80 年代较高，此后呈下降趋势。诊断时年龄较小（18-34 岁比>64 岁：比值比 [OR] = 1.537，95%置信区间 [CI] = 1.007-2.347；35-64 岁比>64 岁：OR = 1.610，95% CI = 1.309-1.979）、男性（OR = 1.518，95% CI = 1.230-1.873）和生活在高学历人群比例较高（>50%比<20%：OR = 8.115，95% CI = 5.053-13.034）的人群中，自杀死亡风险显著增加。
结论
本研究结果可提高临床医生对有自杀风险的白血病患者的认识，并为其提供适当的支持。
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