Rh(I)催化的 2-吡啶酮与羧酸和酸酐的 C6-选择性脱羰基烷基化反应。
Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides.
机构信息
Department of Chemistry, Renmin University of China, Beijing 100872, China.
Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
出版信息
Org Lett. 2020 Jun 5;22(11):4228-4234. doi: 10.1021/acs.orglett.0c01277. Epub 2020 May 8.
A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones with good functional group tolerance.
A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones with good functional group tolerance.
中文译文
A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones with good functional group tolerance.
中文译文
介绍了一种 Rh 催化的螯合辅助 C6 选择性 C-H 活化/烷基化 2-吡啶酮与易得的烷基羧酸或酸酐的反应。反应通过底物脱羰进行。这种方法将 C-H 官能化与易得的酸酐结合在一起，允许高效合成具有良好官能团耐受性的各种 C6-烷基化 2-吡啶酮。
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