Stenberg P E
Department of Laboratory Medicine, University of California, San Francisco 94143.
Scanning Microsc. 1988 Dec;2(4):2117-27.
Morphologic and phenotypic changes occur during the maturation of megakaryocytes (MK) from the pluripotent stem cell to platelets. As the MK acquires organelles, it also acquires membrane glycoproteins and granule contents. Platelet membrane GP IIb/IIIa and platelet peroxidase are present from early stages of maturation to the final product of the megakaryocyte, the platelet, while Ia-like antigen appears to be expressed only during early stages of maturation. The MK synthesizes increasing amounts of lysosomal enzymes, GP Ib, and alpha granule proteins as it matures from the megakaryoblast stage to the mature cell. The platelet contains only vestiges of a protein synthetic apparatus; it therefore has acquired most of its contents, except for serotonin, during the maturation of the MK.
在多能干细胞向血小板成熟的过程中，巨核细胞（MK）会发生形态和表型变化。随着巨核细胞获得细胞器，它也会获得膜糖蛋白和颗粒内容物。血小板膜糖蛋白IIb/IIIa和血小板过氧化物酶从成熟早期到巨核细胞的最终产物血小板都存在，而Ia样抗原似乎仅在成熟早期表达。当巨核细胞从原始巨核细胞阶段成熟为成熟细胞时，它会合成越来越多的溶酶体酶、糖蛋白Ib和α颗粒蛋白。血小板仅含有蛋白质合成装置的残余物；因此，除了5-羟色胺外，它的大部分内容物都是在巨核细胞成熟过程中获得的。
