Kimura Sakiko, Emoto Akiko, Yoshimura Mariko, Arimizu Kota, Kamura Tomoko, Sogawa Rintaro, Mizuta Kikumi, Tagomori Yasuhiro, Natsuaki Masahiro, Kajiwara Masataka, Tsuruoka Nanae, Yakushiji Yusuke, Tanigawa Yoshinori, Takamatsu Chihiro, Danjo Atsushi, Kamohara Keiji, Hirakawa Naomi, Sakaguchi Yoshiro, Noguchi Mitsuru, Noshiro Hirokazu, Kawaguchi Atsushi, Sueoka Eisaburo, Narisawa Yutaka, Kimura Shinya
Safety Management Section, Saga University Hospital.
Dep. of Pharmacy, Saga University Hospital.
Medicine (Baltimore). 2020 May;99(19):e20142. doi: 10.1097/MD.0000000000020142.
Before surgery and other invasive treatments, decisions must be made on whether to discontinue drugs and provide appropriate drug holidays especially for antithrombotic drugs, and this is made difficult by the large number of available drugs and associated guidelines. We have therefore developed an online application for perioperative drug discontinuation and resumption management, named Saga Application for Management of Drug Holidays in PeriOperative Periods (SAMPOP).Multidisciplinary medical staff at Saga University Hospital (SUH) worked together to build an evidence-based Perioperative Drug Discontinuation Management Database (PDDMD) and developed the user-friendly SAMPOP online application via preliminary verification at SUH. From September 2018 to February 2020, 420 medical staff at SUH, including physicians, nurses, and pharmacists, installed and tested SAMPOP.Rate per surgical procedure for forgetting to discontinue antithrombotic drugs preoperatively decreased from 0.18% to 0.09% as of August 2019, 12 months after the introduction of SAMPOP (P = .1359). In addition, six months later, it decreased further to 0.03% as of February 2020 (P = .0436). Forgetting to resume antithrombotic drugs postoperatively decreased from 0.20% to 0.02% as of August 2019, 12 months after the introduction of SAMPOP (P = .0008). There was no case of forgetting to resume the medication in the last 6 months.SAMPOP may be useful for management of drug holidays in the clinic and warrants further evaluation of its safety and efficacy.
在手术和其他侵入性治疗之前，必须决定是否停用药物并提供适当的药物假期，尤其是抗血栓药物，而大量可用药物和相关指南使得这一决策变得困难。因此，我们开发了一个用于围手术期药物停用和恢复管理的在线应用程序，名为围手术期药物假期管理佐贺应用程序（SAMPOP）。佐贺大学医院（SUH）的多学科医务人员共同建立了一个基于证据的围手术期药物停用管理数据库（PDDMD），并通过在SUH的初步验证开发了用户友好的SAMPOP在线应用程序。从2018年9月到2020年2月，SUH的420名医务人员，包括医生、护士和药剂师，安装并测试了SAMPOP。截至2019年8月，即引入SAMPOP后的12个月，术前忘记停用抗血栓药物的每个手术程序发生率从0.18%降至0.09%（P = 0.1359）。此外，6个月后，截至2020年2月，该发生率进一步降至0.03%（P = 0.0436）。术后忘记恢复使用抗血栓药物的情况截至2019年8月，即引入SAMPOP后的12个月，从0.20%降至0.02%（P = 0.0008）。在过去6个月中没有忘记恢复用药的情况。SAMPOP可能对临床药物假期管理有用，值得进一步评估其安全性和有效性。
