Division of Infection and Immunity, University College London, London, United Kingdom; Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United Kingdom.
Division of Infection and Immunity, University College London, London, United Kingdom.
J Allergy Clin Immunol. 2020 May;145(5):1323-1331. doi: 10.1016/j.jaci.2020.03.016.
Aging is a global burden, and the increase in life span does not increase in parallel with health span. Therefore, older adults are currently living longer with chronic diseases, increased infections, and cancer. A characteristic of aging is the presence of chronic low-grade inflammation that is characterized by elevated concentrations of IL-6, TNF-α, and C-reactive protein, which has been termed inflammaging. Previous studies have demonstrated that chronic inflammation interferes with T-cell response and macrophage function and is also detrimental for vaccine responses. This raises the question of whether therapeutic strategies that reduce inflammation may be useful for improving immunity in older adults. In this review we discuss the potential causes of inflammaging, the cellular source of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity. Finally, we describe existing interventions that target inflammation that have been used to enhance immunity during aging.
衰老是一个全球性的负担，寿命的延长并没有与健康寿命平行增加。因此，老年人目前正随着慢性疾病、感染和癌症的增加而长寿。衰老的一个特征是存在慢性低度炎症，其特征是白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和 C 反应蛋白（CRP）浓度升高，这被称为炎症衰老。先前的研究表明，慢性炎症会干扰 T 细胞反应和巨噬细胞功能，对疫苗反应也有害。这就提出了一个问题，即是否可以通过减少炎症的治疗策略来提高老年人的免疫力。在这篇综述中，我们讨论了炎症衰老的潜在原因、炎症介质的细胞来源以及炎症可能抑制免疫的机制。最后，我们描述了现有的针对炎症的干预措施，这些措施已被用于增强衰老过程中的免疫力。
