Anguelova Galia V, Vlak Monique H M, Kurvers Arthur G Y, Rijsman Roselyne M
Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, The Netherlands.
Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, The Netherlands.
Sleep Med Clin. 2020 Jun;15(2):277-288. doi: 10.1016/j.jsmc.2020.02.013.
This article provides an updated practical guide for the treatment of primary restless legs syndrome (RLS). Articles that appeared after the American Academy of Neurology guideline search were reviewed according to the same evidence rating schedule. We found limited evidence for nonpharmacologic treatment options. In moderate to severe primary RLS, pharmacologic options may be considered, including iron suppletion, an α2δ ligand, a dopamine agonist, a combination of an α2δ ligand and a dopamine agonist, or oxycodone/naloxone. This article includes treatment options in case of augmentation.
本文提供了一份关于原发性不宁腿综合征（RLS）治疗的最新实用指南。根据相同的证据评级表，对美国神经病学学会指南搜索之后出现的文章进行了审查。我们发现非药物治疗选择的证据有限。对于中度至重度原发性RLS，可考虑药物治疗选择，包括补充铁剂、一种α2δ配体、一种多巴胺激动剂、一种α2δ配体和一种多巴胺激动剂的组合，或羟考酮/纳洛酮。本文还包括了出现增敏现象时的治疗选择。
