Burgess Helen J, Emens Jonathan S
Biological Rhythms Research Laboratory, Department of Behavioral Sciences, Rush University Medical Center, 1645 West Jackson Boulevard, Suite 425, Chicago, IL 60612, USA.
Department of Psychiatry, Oregon Health & Science University, VA Portland Health Care System, 3710 Southwest US Veterans Hospital, Road P3-PULM, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, VA Portland Health Care System, 3710 Southwest US Veterans Hospital, Road P3-PULM, Portland, OR 97239, USA.
Sleep Med Clin. 2020 Jun;15(2):301-310. doi: 10.1016/j.jsmc.2020.02.015.
This article focuses on melatonin and other melatonin receptor agonists, and specifically their circadian phase shifting and sleep-enhancing properties. The circadian system and circadian rhythm sleep-wake disorders are briefly reviewed, followed by a summary of the circadian phase shifting, sleep-enhancing properties, and possible safety concerns associated with melatonin and other melatonin receptor agonists. The recommended use of melatonin, including dose and timing, in the latest American Academy of Sleep Medicine Clinical Practice Guidelines for the treatment of intrinsic circadian rhythm disorders is also reviewed. Lastly, the practical aspects of treatment and consideration of clinical treatment outcomes are discussed.
本文聚焦于褪黑素及其他褪黑素受体激动剂，尤其关注它们的昼夜节律相移和助眠特性。本文简要回顾了昼夜节律系统及昼夜节律性睡眠-觉醒障碍，随后总结了褪黑素及其他褪黑素受体激动剂的昼夜节律相移、助眠特性以及可能存在的安全问题。文中还回顾了美国睡眠医学学会最新临床实践指南中关于褪黑素治疗内在昼夜节律障碍的推荐用法，包括剂量和服用时间。最后，讨论了治疗的实际情况及对临床治疗效果的考量。
