PhyMedExp, Université Montpellier, INSERM, CNRS, France.
IRMB, Université Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Food Chem Toxicol. 2020 Jul;141:111403. doi: 10.1016/j.fct.2020.111403. Epub 2020 May 6.
The prevalence of metabolic syndrome (MetS), elevating cardiovascular risks, is increasing worldwide, with no available global therapeutic options. The intake of plain, mineral or biocompatible modified waters was shown to prevent some MetS features. This study was designed to analyze, in mice fed a high fat and sucrose diet (HFSD), the effects on MetS features of the daily intake of a reverse osmosed, weakly remineralized, water (OW) and of an OW dynamized by a physical processing (ODW), compared to tap water (TW). The HFSD was effective at inducing major features of MetS such as obesity, hepatic steatosis and inflammation, blood dyslipidemia, systemic glucose intolerance and muscle insulin resistance. Compared to TW, OW intake decreased hepatic fibrosis and inflammation, and mitigated hepatic steatosis and dyslipidemia. ODW intake further improved skeletal muscle insulin sensitivity and systemic glucose tolerance. This study highlights the deleterious metabolic impacts of the daily intake of TW, in combination with a high energy diet, and its possible involvement in MetS prevalence increase. In addition, it demonstrates that biocompatible modified water may be promising non-pharmaceutical, cost-effective tools for nutritional approaches in the treatment of MetS.
代谢综合征（MetS）的流行率不断上升，增加了心血管风险，目前全球尚无有效的治疗方法。研究表明，饮用普通、矿化或生物相容的改良水可以预防部分 MetS 特征。本研究旨在分析高脂高糖饮食（HFSD）喂养的小鼠中，每日摄入反渗透、弱矿化水（OW）和经物理处理动态化的 OW（ODW）对 MetS 特征的影响，并与自来水（TW）进行比较。HFSD 可有效诱导 MetS 的主要特征，如肥胖、肝脂肪变性和炎症、血液血脂异常、全身葡萄糖不耐受和肌肉胰岛素抵抗。与 TW 相比，OW 摄入可减少肝纤维化和炎症，并减轻肝脂肪变性和血脂异常。ODW 摄入可进一步改善骨骼肌胰岛素敏感性和全身葡萄糖耐量。本研究强调了 TW 与高能量饮食联合摄入对代谢的有害影响，并可能与 MetS 流行率增加有关。此外，它还表明，生物相容的改良水可能是治疗 MetS 的非药物、具有成本效益的营养方法的有前途的工具。
