Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Endocrinology and Second Department of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Behav Brain Res. 2020 Jul 15;390:112660. doi: 10.1016/j.bbr.2020.112660. Epub 2020 May 7.
Exposure to maternal high-fat (HF) diet during gestation and lactation alters adult offspring's feeding behavior and diet preference. However, the impact of maternal exercise on offspring's diet preference and reward system development is less studied. In this study, we investigate the effect of perinatal maternal exercise on the development of diet preference, dopamine- and opioid-related gene expression in the central reward system in female offspring from HF-fed Sprague-Dawley rat dams. We found maternal HF diet did not alter adult offspring HF preference, but influenced offspring's dopamine and opioid system both at weaning and in adulthood, and these offspring retained higher body weight in adulthood. However, offspring from dams exposed to both HF diet and exercise during gestation and lactation had normalized body weight, decreased fat mass and lower HF-diet preference but increased energy intake in adulthood. The dopamine- and opioid-related gene expression in central reward system and POMC expression in hypothalamus was elevated in these adult offspring. We conclude that maternal exercise during gestation and lactation can potentially overcome the negative effects of perinatal exposure to HF diet in female offspring by altering their diet preference, central reward system signaling and hypothalamus neuropeptide expression.
孕期和哺乳期接触母体高脂肪（HF）饮食会改变成年后代的进食行为和饮食偏好。然而，母体运动对后代饮食偏好和奖励系统发育的影响研究较少。在这项研究中，我们调查了围产期母体运动对 HF 喂养的 Sprague-Dawley 大鼠母鼠后代的中央奖励系统中与多巴胺和阿片类物质相关的基因表达和饮食偏好发展的影响。我们发现，母体 HF 饮食不会改变成年后代对 HF 的偏好，但会影响后代在断奶和成年期的多巴胺和阿片系统，并且这些后代在成年期保留更高的体重。然而，来自在妊娠和哺乳期同时暴露于 HF 饮食和运动的母鼠的后代在成年期体重正常化，脂肪量减少，HF 饮食偏好降低，但能量摄入增加。这些成年后代的中央奖励系统中的多巴胺和阿片类物质相关基因表达以及下丘脑 POMC 表达升高。我们得出结论，母体在妊娠和哺乳期的运动可以通过改变后代的饮食偏好、中央奖励系统信号和下丘脑神经肽表达，潜在地克服围产期暴露于 HF 饮食对雌性后代的负面影响。
