Quantitative Medical Imaging Systems Group (QMISG), Research Center for Molecular and Cellular Imaging (RCMCI), Tehran Unievrsity of Medical Sciences (TUMS), Tehran, Iran; Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Quantitative Medical Imaging Systems Group (QMISG), Research Center for Molecular and Cellular Imaging (RCMCI), Tehran Unievrsity of Medical Sciences (TUMS), Tehran, Iran; Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Magn Reson Imaging. 2020 Sep;71:17-24. doi: 10.1016/j.mri.2020.04.014. Epub 2020 May 6.
The purpose of our study was to use Dual-TR STE-MR protocol as a clinical tool for cortical bone free water quantification at 1.5 T and validate it by comparing the obtained results (MR-derived results) with dehydration results.
Human studies were compliant with HIPPA and were approved by the institutional review board. Short Echo Time (STE) MR imaging with different Repetition Times (TRs) was used for quantification of cortical bone free water T (Tfree) and concentration (ρ). The proposed strategy was compared with the dehydration technique in seven bovine cortical bone samples. The agreement between the two methods was quantified by using Bland and Altman analysis. Then we applied the technique on a cross-sectional population of thirty healthy volunteers (18F/12M) and examined the association of the biomarkers with age.
The mean values of ρ for bovine cortical bone specimens were quantified as 4.37% and 5.34% by using STE-MR and dehydration techniques, respectively. The Bland and Altman analysis showed good agreement between the two methods along with the suggestion of 0.99% bias between them. Strong correlations were also reported between ρ (r = 0.62) and T and age (r = 0.8). The reproducibility of the method, evaluated in eight subjects, yielded an intra-class correlation of 0.95.
STE-MR imaging with dual-TR strategy is a clinical solution for quantifying cortical bone ρ and T.
我们研究的目的是使用双重复时间（Dual-TR）STE-MR 协议作为在 1.5T 下测量皮质骨游离水的临床工具，并通过将获得的结果（MR 衍生结果）与脱水结果进行比较来验证其准确性。
人体研究符合 HIPAA 规定，并获得了机构审查委员会的批准。使用不同重复时间（TR）的短回波时间（STE）MR 成像来定量测量皮质骨游离水 T（Tfree）和浓度（ρ）。将提出的策略与脱水技术在七个牛皮质骨样本中进行比较。使用 Bland 和 Altman 分析来量化两种方法之间的一致性。然后，我们将该技术应用于 30 名健康志愿者的横断面人群中（18F/12M），并检查了生物标志物与年龄的相关性。
使用 STE-MR 和脱水技术分别定量测量牛皮质骨标本的 ρ 值，平均值分别为 4.37%和 5.34%。Bland 和 Altman 分析表明，两种方法之间具有良好的一致性，并提示两者之间存在 0.99%的偏差。还报告了 ρ（r=0.62）和 T 与年龄之间的强相关性（r=0.8）。在 8 名受试者中评估的方法的可重复性产生了 0.95 的组内相关系数。
使用双重复时间策略的 STE-MR 成像技术是一种定量测量皮质骨 ρ 和 T 的临床解决方案。
