[乙酰乙酸对大鼠肝脏线粒体氧化3-羟基丁酸的影响]
[The effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria].
作者信息
Koshkin V V
出版信息
Ukr Biokhim Zh (1978). 1988 Nov-Dec;60(6):79-82.
PMID:3238802
Abstract
Effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria is described. State 3 respiration is inhibited by acetoacetate, while state 4 respiration is not inhibited, though cytochrome c reduction was decreased. Acetoacetate is also non-competitive inhibitor of 3-hydroxybutyrateoxidase and 3-hydroxybutyrate dehydrogenase activity in frozen-thawed mitochondria. The results are discussed in terms of the thermodynamic hypothesis and control strength method.
摘要
描述了乙酰乙酸对大鼠肝脏线粒体氧化3-羟基丁酸的影响。乙酰乙酸抑制状态3呼吸，而状态4呼吸不受抑制，尽管细胞色素c还原减少。乙酰乙酸也是冻融线粒体中3-羟基丁酸氧化酶和3-羟基丁酸脱氢酶活性的非竞争性抑制剂。根据热力学假说和控制强度方法对结果进行了讨论。
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