Department of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA.
Department of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA.
Curr Opin Microbiol. 2020 Jun;55:81-87. doi: 10.1016/j.mib.2020.03.004. Epub 2020 May 7.
As investigators decipher the underlining mechanisms of Staphylococcus aureus pathogenesis, it is becoming apparent that perturbations in central metabolism alter virulence factor production and infection outcomes. It is also evident that S. aureus has the ability to metabolically adapt to improve colonization and overcome challenges imparted by the immune system. Altered metabolite pools modify virulence factor production suggesting that proper functioning of a core metabolic network is necessary for successful niche colonization and pathogenesis. Herein we discuss four examples of transcriptional regulators that monitor metabolic status. These regulatory systems sense perturbations in the metabolic network and respond by altering the transcription of genes utilized for central metabolism, energy generation and pathogenesis.
随着研究人员对金黄色葡萄球菌发病机制的深入研究，越来越明显的是，中心代谢的紊乱会改变毒力因子的产生和感染结果。此外，金黄色葡萄球菌具有代谢适应的能力，以改善定植和克服免疫系统带来的挑战。代谢物池的改变会改变毒力因子的产生，这表明核心代谢网络的正常功能对于成功的生态位定植和发病机制是必要的。在这里，我们讨论了四个监测代谢状态的转录调节因子的例子。这些调节系统感知代谢网络的扰动，并通过改变用于中心代谢、能量产生和发病机制的基因的转录来做出响应。
