Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Breast. 2020 Aug;52:58-63. doi: 10.1016/j.breast.2020.04.010. Epub 2020 Apr 29.
By the time they complete breast cancer therapy, many young patients are still of childbearing age. We aim to estimate the incidence of pregnancies in women who completed treatment and examine the percentage of patients who received fertility counseling before initiation of therapy.
Electronic health records of breast cancer patients between 2008 and 2014 at AUBMC were screened for exclusion criteria of having metastatic disease or known infertility, still receiving therapy, and being above 42 years at diagnosis. Data about therapy and tumor characteristics was obtained for the included survivors who were interviewed as well via telephone for information about fertility preservation counseling, pregnancy occurrence, and delivery.
451 breast cancer patients were identified. 39 patients remained after application of exclusion criteria. 30.76% (n = 12) wanted more children at the time of diagnosis. 10.25% (n = 4) of all 39 patients treated for breast cancer achieved one or more pregnancy after a median time of 3.83 years after completion of therapy. 25% (n = 3) of women who wanted more children at diagnosis (n = 12) were able to conceive. 23.07% (n = 9) of patients discussed fertility with their primary oncologist prior to treatment initiation. 35.89% (n = 14) of patients were aware of fertility preservation technique availability, but none of these patients used one.
The observed rate of pregnancy is comparable to the literature. There is a lack in fertility counseling of breast cancer patients, and the rate of use of fertility preservation techniques is very low despite prior knowledge about their availability.
许多年轻的乳腺癌患者在完成治疗后仍处于生育年龄。我们旨在评估完成治疗的女性怀孕的发生率，并检查在开始治疗前接受生育咨询的患者比例。
筛查 2008 年至 2014 年在 AUBMC 接受治疗的乳腺癌患者的电子健康记录，排除有转移性疾病或已知不孕、仍在接受治疗以及诊断时年龄超过 42 岁的患者。对符合条件的幸存者进行了数据收集，包括治疗和肿瘤特征，并通过电话采访了她们关于生育保护咨询、怀孕发生和分娩的信息。
共确定了 451 例乳腺癌患者，应用排除标准后有 39 例患者符合条件。30.76%（n=12）的患者在诊断时希望有更多的孩子。在所有接受乳腺癌治疗的 39 例患者中，有 10.25%（n=4）在完成治疗后 3.83 年中位数时间后成功怀孕。在诊断时希望有更多孩子的 12 名患者中，有 25%（n=3）能够怀孕。在治疗开始前，有 23.07%（n=9）的患者与他们的初级肿瘤学家讨论过生育问题。35.89%（n=14）的患者知道生育保护技术的可用性，但没有患者使用。
观察到的怀孕率与文献相符。乳腺癌患者的生育咨询不足，尽管事先了解到生育保护技术的可用性，但使用这些技术的比例非常低。
