Atilola M A, Bailey C S, Morgan J P
Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
Vet Surg. 1988 May-Jun;17(3):135-40. doi: 10.1111/j.1532-950x.1988.tb00291.x.
Cervical chemonucleolysis performed surgically in 16 clinically normal 4 and 10 year old Beagle dogs was well tolerated. The dosage of chymopapain per intervertebral disc was 200 or 500 U. Disc space narrowing was radiographically visible by day 1. By gross and histologic examination, there was lysis of the nucleus pulposus (NP) and perinuclear annulus fibrosus (AF). No observable differences due to ages of the dogs or doses of the enzyme were seen.
对16只4岁和10岁临床健康的比格犬进行的手术化学髓核溶解术耐受性良好。每个椎间盘的木瓜凝乳蛋白酶剂量为200或500单位。术后第1天X线片可见椎间盘间隙变窄。大体和组织学检查显示，髓核（NP）和核周纤维环（AF）溶解。未观察到因犬只年龄或酶剂量不同而产生的差异。
