Chen X X, Sun Y
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Ministery of Education Key Laboratory of Population Health Across Life Cycle, Hefei 230032, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 May 6;54(5):581-585. doi: 10.3760/cma.j.cn112150-20190624-00503.
Early life adversity is a risk factor for many diseases, but the related mechanism is not clear. Some research clues suggest that early life adversity is related to biological aging, and at present, the more recognized biological aging index is telomere length. Therefore, exploring the relationship between early life adversity and telomere length is of great significance to reveal the related mechanism of adversity. Through a review of previous literature, this paper discusses the possible effects of different adversity types, exposure time and research design on the relationship between early life adversity and telomere length, so as to provide a basis for the intervention of early life adversity.
早年生活逆境是许多疾病的危险因素，但其相关机制尚不清楚。一些研究线索表明，早年生活逆境与生物衰老有关，目前，更被认可的生物衰老指标是端粒长度。因此，探索早年生活逆境与端粒长度之间的关系对于揭示逆境相关机制具有重要意义。通过回顾以往文献，本文探讨了不同逆境类型、暴露时间和研究设计对早年生活逆境与端粒长度关系的可能影响，以便为早年生活逆境的干预提供依据。
